Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation

Ultrahigh resolution optical coherence tomography (UHR-OCT) for differentiating pituitary gland versus adenoma tissue has been investigated for the first time, indicating more than 80% accuracy. For biomarker identification, OCT images of paraffin embedded tissue are correlated to histopathological...

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Autores principales: Placzek, Fabian, Micko, Alexander, Sentosa, Ryan, Fonollà, Roger, Winklehner, Michael, Hosmann, Arthur, Andreana, Marco, Höftberger, Romana, Drexler, Wolfgang, Leitgeb, Rainer A., Wolfsberger, Stefan, Unterhuber, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747926/
https://www.ncbi.nlm.nih.gov/pubmed/33408976
http://dx.doi.org/10.1364/BOE.409987
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author Placzek, Fabian
Micko, Alexander
Sentosa, Ryan
Fonollà, Roger
Winklehner, Michael
Hosmann, Arthur
Andreana, Marco
Höftberger, Romana
Drexler, Wolfgang
Leitgeb, Rainer A.
Wolfsberger, Stefan
Unterhuber, Angelika
author_facet Placzek, Fabian
Micko, Alexander
Sentosa, Ryan
Fonollà, Roger
Winklehner, Michael
Hosmann, Arthur
Andreana, Marco
Höftberger, Romana
Drexler, Wolfgang
Leitgeb, Rainer A.
Wolfsberger, Stefan
Unterhuber, Angelika
author_sort Placzek, Fabian
collection PubMed
description Ultrahigh resolution optical coherence tomography (UHR-OCT) for differentiating pituitary gland versus adenoma tissue has been investigated for the first time, indicating more than 80% accuracy. For biomarker identification, OCT images of paraffin embedded tissue are correlated to histopathological slices. The identified biomarkers are verified on fresh biopsies. Additionally, an approach, based on resolution modified UHR-OCT ex vivo data, investigating optical performance parameters for the realization in an in vivo endoscope is presented and evaluated. The identified morphological features–cell groups with reticulin framework–detectable with UHR-OCT showcase a promising differentiation ability, encouraging endoscopic OCT probe development for in vivo application.
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spelling pubmed-77479262021-01-05 Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation Placzek, Fabian Micko, Alexander Sentosa, Ryan Fonollà, Roger Winklehner, Michael Hosmann, Arthur Andreana, Marco Höftberger, Romana Drexler, Wolfgang Leitgeb, Rainer A. Wolfsberger, Stefan Unterhuber, Angelika Biomed Opt Express Article Ultrahigh resolution optical coherence tomography (UHR-OCT) for differentiating pituitary gland versus adenoma tissue has been investigated for the first time, indicating more than 80% accuracy. For biomarker identification, OCT images of paraffin embedded tissue are correlated to histopathological slices. The identified biomarkers are verified on fresh biopsies. Additionally, an approach, based on resolution modified UHR-OCT ex vivo data, investigating optical performance parameters for the realization in an in vivo endoscope is presented and evaluated. The identified morphological features–cell groups with reticulin framework–detectable with UHR-OCT showcase a promising differentiation ability, encouraging endoscopic OCT probe development for in vivo application. Optical Society of America 2020-11-09 /pmc/articles/PMC7747926/ /pubmed/33408976 http://dx.doi.org/10.1364/BOE.409987 Text en Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) . Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
spellingShingle Article
Placzek, Fabian
Micko, Alexander
Sentosa, Ryan
Fonollà, Roger
Winklehner, Michael
Hosmann, Arthur
Andreana, Marco
Höftberger, Romana
Drexler, Wolfgang
Leitgeb, Rainer A.
Wolfsberger, Stefan
Unterhuber, Angelika
Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation
title Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation
title_full Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation
title_fullStr Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation
title_full_unstemmed Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation
title_short Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation
title_sort towards ultrahigh resolution oct based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747926/
https://www.ncbi.nlm.nih.gov/pubmed/33408976
http://dx.doi.org/10.1364/BOE.409987
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