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Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 70...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Lippincott Williams & Wilkins
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748049/ https://www.ncbi.nlm.nih.gov/pubmed/33321069 http://dx.doi.org/10.1161/CIRCGEN.119.002769 |
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| author | van Zuydam, Natalie R. Ladenvall, Claes Voight, Benjamin F. Strawbridge, Rona J. Fernandez-Tajes, Juan Rayner, N. William Robertson, Neil R. Mahajan, Anubha Vlachopoulou, Efthymia Goel, Anuj Kleber, Marcus E. Nelson, Christopher P. Kwee, Lydia Coulter Esko, Tõnu Mihailov, Evelin Mägi, Reedik Milani, Lili Fischer, Krista Kanoni, Stavroula Kumar, Jitender Song, Ci Hartiala, Jaana A. Pedersen, Nancy L. Perola, Markus Gieger, Christian Peters, Annette Qu, Liming Willems, Sara M. Doney, Alex S.F. Morris, Andrew D. Zheng, Yan Sesti, Giorgio Hu, Frank B. Qi, Lu Laakso, Markku Thorsteinsdottir, Unnur Grallert, Harald van Duijn, Cornelia Reilly, Muredach P. Ingelsson, Erik Deloukas, Panos Kathiresan, Sek Metspalu, Andres Shah, Svati H. Sinisalo, Juha Salomaa, Veikko Hamsten, Anders Samani, Nilesh J. März, Winfried Hazen, Stanley L. Watkins, Hugh Saleheen, Danish Morris, Andrew P. Colhoun, Helen M. Groop, Leif McCarthy, Mark I. Palmer, Colin N.A. |
| author_facet | van Zuydam, Natalie R. Ladenvall, Claes Voight, Benjamin F. Strawbridge, Rona J. Fernandez-Tajes, Juan Rayner, N. William Robertson, Neil R. Mahajan, Anubha Vlachopoulou, Efthymia Goel, Anuj Kleber, Marcus E. Nelson, Christopher P. Kwee, Lydia Coulter Esko, Tõnu Mihailov, Evelin Mägi, Reedik Milani, Lili Fischer, Krista Kanoni, Stavroula Kumar, Jitender Song, Ci Hartiala, Jaana A. Pedersen, Nancy L. Perola, Markus Gieger, Christian Peters, Annette Qu, Liming Willems, Sara M. Doney, Alex S.F. Morris, Andrew D. Zheng, Yan Sesti, Giorgio Hu, Frank B. Qi, Lu Laakso, Markku Thorsteinsdottir, Unnur Grallert, Harald van Duijn, Cornelia Reilly, Muredach P. Ingelsson, Erik Deloukas, Panos Kathiresan, Sek Metspalu, Andres Shah, Svati H. Sinisalo, Juha Salomaa, Veikko Hamsten, Anders Samani, Nilesh J. März, Winfried Hazen, Stanley L. Watkins, Hugh Saleheen, Danish Morris, Andrew P. Colhoun, Helen M. Groop, Leif McCarthy, Mark I. Palmer, Colin N.A. |
| author_sort | van Zuydam, Natalie R. |
| collection | PubMed |
| description | Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D). RESULTS: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. CONCLUSIONS: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D. |
| format | Online Article Text |
| id | pubmed-7748049 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Lippincott Williams & Wilkins |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77480492020-12-22 Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus van Zuydam, Natalie R. Ladenvall, Claes Voight, Benjamin F. Strawbridge, Rona J. Fernandez-Tajes, Juan Rayner, N. William Robertson, Neil R. Mahajan, Anubha Vlachopoulou, Efthymia Goel, Anuj Kleber, Marcus E. Nelson, Christopher P. Kwee, Lydia Coulter Esko, Tõnu Mihailov, Evelin Mägi, Reedik Milani, Lili Fischer, Krista Kanoni, Stavroula Kumar, Jitender Song, Ci Hartiala, Jaana A. Pedersen, Nancy L. Perola, Markus Gieger, Christian Peters, Annette Qu, Liming Willems, Sara M. Doney, Alex S.F. Morris, Andrew D. Zheng, Yan Sesti, Giorgio Hu, Frank B. Qi, Lu Laakso, Markku Thorsteinsdottir, Unnur Grallert, Harald van Duijn, Cornelia Reilly, Muredach P. Ingelsson, Erik Deloukas, Panos Kathiresan, Sek Metspalu, Andres Shah, Svati H. Sinisalo, Juha Salomaa, Veikko Hamsten, Anders Samani, Nilesh J. März, Winfried Hazen, Stanley L. Watkins, Hugh Saleheen, Danish Morris, Andrew P. Colhoun, Helen M. Groop, Leif McCarthy, Mark I. Palmer, Colin N.A. Circ Genom Precis Med Original Articles Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D). RESULTS: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. CONCLUSIONS: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D. Lippincott Williams & Wilkins 2020-08-13 /pmc/articles/PMC7748049/ /pubmed/33321069 http://dx.doi.org/10.1161/CIRCGEN.119.002769 Text en © 2020 The Authors. https://creativecommons.org/licenses/by/4.0/Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited. |
| spellingShingle | Original Articles van Zuydam, Natalie R. Ladenvall, Claes Voight, Benjamin F. Strawbridge, Rona J. Fernandez-Tajes, Juan Rayner, N. William Robertson, Neil R. Mahajan, Anubha Vlachopoulou, Efthymia Goel, Anuj Kleber, Marcus E. Nelson, Christopher P. Kwee, Lydia Coulter Esko, Tõnu Mihailov, Evelin Mägi, Reedik Milani, Lili Fischer, Krista Kanoni, Stavroula Kumar, Jitender Song, Ci Hartiala, Jaana A. Pedersen, Nancy L. Perola, Markus Gieger, Christian Peters, Annette Qu, Liming Willems, Sara M. Doney, Alex S.F. Morris, Andrew D. Zheng, Yan Sesti, Giorgio Hu, Frank B. Qi, Lu Laakso, Markku Thorsteinsdottir, Unnur Grallert, Harald van Duijn, Cornelia Reilly, Muredach P. Ingelsson, Erik Deloukas, Panos Kathiresan, Sek Metspalu, Andres Shah, Svati H. Sinisalo, Juha Salomaa, Veikko Hamsten, Anders Samani, Nilesh J. März, Winfried Hazen, Stanley L. Watkins, Hugh Saleheen, Danish Morris, Andrew P. Colhoun, Helen M. Groop, Leif McCarthy, Mark I. Palmer, Colin N.A. Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus |
| title | Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus |
| title_full | Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus |
| title_fullStr | Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus |
| title_full_unstemmed | Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus |
| title_short | Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus |
| title_sort | genetic predisposition to coronary artery disease in type 2 diabetes mellitus |
| topic | Original Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748049/ https://www.ncbi.nlm.nih.gov/pubmed/33321069 http://dx.doi.org/10.1161/CIRCGEN.119.002769 |
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