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Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection

The entry of SARS-CoV-2 into target cells requires the activation of its surface spike protein, S, by host proteases. The host serine protease TMPRSS2 and cysteine proteases Cathepsin B/L can activate S, making two independent entry pathways accessible to SARS-CoV-2. Blocking the proteases prevents...

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Detalles Bibliográficos
Autores principales:	Padmanabhan, Pranesh, Desikan, Rajat, Dixit, Narendra M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748278/ https://www.ncbi.nlm.nih.gov/pubmed/33290397 http://dx.doi.org/10.1371/journal.pcbi.1008461

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