Cargando…
The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis
BACKGROUND: Hepatoma-derived growth factor (HDGF) promotes cancer progression and metastasis by interacting with vascular endothelial growth factor, thereby inducing epithelial-to-mesenchymal transition and angiogenesis. Recent studies have correlated increased HDGF levels with poor prognosis in var...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748309/ https://www.ncbi.nlm.nih.gov/pubmed/33371164 http://dx.doi.org/10.1097/MD.0000000000023837 |
_version_ | 1783625086738104320 |
---|---|
author | Koh, Hyun Min Hyun, Chang Lim Jang, Bo Gun Lee, Hyun Ju |
author_facet | Koh, Hyun Min Hyun, Chang Lim Jang, Bo Gun Lee, Hyun Ju |
author_sort | Koh, Hyun Min |
collection | PubMed |
description | BACKGROUND: Hepatoma-derived growth factor (HDGF) promotes cancer progression and metastasis by interacting with vascular endothelial growth factor, thereby inducing epithelial-to-mesenchymal transition and angiogenesis. Recent studies have correlated increased HDGF levels with poor prognosis in various malignancies, including lung cancer. This meta-analysis systematically assessed the prognostic significance of HDGF expression in patients with non-small cell lung cancer (NSCLC). METHODS: Eligible studies were identified by searching literature in PubMed, Embase, Scopus, and the Cochrane library until June 2020. The pooled hazard ratio (HR) or odds ratio (OR) with 95% confidence interval (CI) was determined to assess the relationship between HDGF expression and clinical outcome in patients with NSCLC. RESULTS: The pooled HRs between high HDGF expression and clinical outcome were 2.20 (95% CI 1.75–2.76, P < .001) and 2.77 (95% CI 1.79–4.29, P < .001) for overall survival and disease-free survival, respectively. High HDGF expression was significantly correlated with a larger tumor size (OR 1.59, 95% CI 1.02–2.46, P = .040). CONCLUSION: HDGF expression is related to clinical outcome and may be a prognostic marker in patients with NSCLC. |
format | Online Article Text |
id | pubmed-7748309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-77483092020-12-21 The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis Koh, Hyun Min Hyun, Chang Lim Jang, Bo Gun Lee, Hyun Ju Medicine (Baltimore) 5700 BACKGROUND: Hepatoma-derived growth factor (HDGF) promotes cancer progression and metastasis by interacting with vascular endothelial growth factor, thereby inducing epithelial-to-mesenchymal transition and angiogenesis. Recent studies have correlated increased HDGF levels with poor prognosis in various malignancies, including lung cancer. This meta-analysis systematically assessed the prognostic significance of HDGF expression in patients with non-small cell lung cancer (NSCLC). METHODS: Eligible studies were identified by searching literature in PubMed, Embase, Scopus, and the Cochrane library until June 2020. The pooled hazard ratio (HR) or odds ratio (OR) with 95% confidence interval (CI) was determined to assess the relationship between HDGF expression and clinical outcome in patients with NSCLC. RESULTS: The pooled HRs between high HDGF expression and clinical outcome were 2.20 (95% CI 1.75–2.76, P < .001) and 2.77 (95% CI 1.79–4.29, P < .001) for overall survival and disease-free survival, respectively. High HDGF expression was significantly correlated with a larger tumor size (OR 1.59, 95% CI 1.02–2.46, P = .040). CONCLUSION: HDGF expression is related to clinical outcome and may be a prognostic marker in patients with NSCLC. Lippincott Williams & Wilkins 2020-12-18 /pmc/articles/PMC7748309/ /pubmed/33371164 http://dx.doi.org/10.1097/MD.0000000000023837 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5700 Koh, Hyun Min Hyun, Chang Lim Jang, Bo Gun Lee, Hyun Ju The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis |
title | The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis |
title_full | The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis |
title_fullStr | The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis |
title_full_unstemmed | The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis |
title_short | The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis |
title_sort | relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: a systematic review and meta-analysis |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748309/ https://www.ncbi.nlm.nih.gov/pubmed/33371164 http://dx.doi.org/10.1097/MD.0000000000023837 |
work_keys_str_mv | AT kohhyunmin therelationshipbetweenhepatomaderivedgrowthfactorandprognosisinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT hyunchanglim therelationshipbetweenhepatomaderivedgrowthfactorandprognosisinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT jangbogun therelationshipbetweenhepatomaderivedgrowthfactorandprognosisinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT leehyunju therelationshipbetweenhepatomaderivedgrowthfactorandprognosisinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT kohhyunmin relationshipbetweenhepatomaderivedgrowthfactorandprognosisinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT hyunchanglim relationshipbetweenhepatomaderivedgrowthfactorandprognosisinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT jangbogun relationshipbetweenhepatomaderivedgrowthfactorandprognosisinnonsmallcelllungcancerasystematicreviewandmetaanalysis AT leehyunju relationshipbetweenhepatomaderivedgrowthfactorandprognosisinnonsmallcelllungcancerasystematicreviewandmetaanalysis |