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The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis

BACKGROUND: Hepatoma-derived growth factor (HDGF) promotes cancer progression and metastasis by interacting with vascular endothelial growth factor, thereby inducing epithelial-to-mesenchymal transition and angiogenesis. Recent studies have correlated increased HDGF levels with poor prognosis in var...

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Autores principales: Koh, Hyun Min, Hyun, Chang Lim, Jang, Bo Gun, Lee, Hyun Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748309/
https://www.ncbi.nlm.nih.gov/pubmed/33371164
http://dx.doi.org/10.1097/MD.0000000000023837
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author Koh, Hyun Min
Hyun, Chang Lim
Jang, Bo Gun
Lee, Hyun Ju
author_facet Koh, Hyun Min
Hyun, Chang Lim
Jang, Bo Gun
Lee, Hyun Ju
author_sort Koh, Hyun Min
collection PubMed
description BACKGROUND: Hepatoma-derived growth factor (HDGF) promotes cancer progression and metastasis by interacting with vascular endothelial growth factor, thereby inducing epithelial-to-mesenchymal transition and angiogenesis. Recent studies have correlated increased HDGF levels with poor prognosis in various malignancies, including lung cancer. This meta-analysis systematically assessed the prognostic significance of HDGF expression in patients with non-small cell lung cancer (NSCLC). METHODS: Eligible studies were identified by searching literature in PubMed, Embase, Scopus, and the Cochrane library until June 2020. The pooled hazard ratio (HR) or odds ratio (OR) with 95% confidence interval (CI) was determined to assess the relationship between HDGF expression and clinical outcome in patients with NSCLC. RESULTS: The pooled HRs between high HDGF expression and clinical outcome were 2.20 (95% CI 1.75–2.76, P < .001) and 2.77 (95% CI 1.79–4.29, P < .001) for overall survival and disease-free survival, respectively. High HDGF expression was significantly correlated with a larger tumor size (OR 1.59, 95% CI 1.02–2.46, P = .040). CONCLUSION: HDGF expression is related to clinical outcome and may be a prognostic marker in patients with NSCLC.
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spelling pubmed-77483092020-12-21 The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis Koh, Hyun Min Hyun, Chang Lim Jang, Bo Gun Lee, Hyun Ju Medicine (Baltimore) 5700 BACKGROUND: Hepatoma-derived growth factor (HDGF) promotes cancer progression and metastasis by interacting with vascular endothelial growth factor, thereby inducing epithelial-to-mesenchymal transition and angiogenesis. Recent studies have correlated increased HDGF levels with poor prognosis in various malignancies, including lung cancer. This meta-analysis systematically assessed the prognostic significance of HDGF expression in patients with non-small cell lung cancer (NSCLC). METHODS: Eligible studies were identified by searching literature in PubMed, Embase, Scopus, and the Cochrane library until June 2020. The pooled hazard ratio (HR) or odds ratio (OR) with 95% confidence interval (CI) was determined to assess the relationship between HDGF expression and clinical outcome in patients with NSCLC. RESULTS: The pooled HRs between high HDGF expression and clinical outcome were 2.20 (95% CI 1.75–2.76, P < .001) and 2.77 (95% CI 1.79–4.29, P < .001) for overall survival and disease-free survival, respectively. High HDGF expression was significantly correlated with a larger tumor size (OR 1.59, 95% CI 1.02–2.46, P = .040). CONCLUSION: HDGF expression is related to clinical outcome and may be a prognostic marker in patients with NSCLC. Lippincott Williams & Wilkins 2020-12-18 /pmc/articles/PMC7748309/ /pubmed/33371164 http://dx.doi.org/10.1097/MD.0000000000023837 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5700
Koh, Hyun Min
Hyun, Chang Lim
Jang, Bo Gun
Lee, Hyun Ju
The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis
title The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis
title_full The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis
title_fullStr The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis
title_full_unstemmed The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis
title_short The relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: A systematic review and meta-analysis
title_sort relationship between hepatoma-derived growth factor and prognosis in non-small cell lung cancer: a systematic review and meta-analysis
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748309/
https://www.ncbi.nlm.nih.gov/pubmed/33371164
http://dx.doi.org/10.1097/MD.0000000000023837
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