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Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors

Curettage of benign bone tumor is a common cause for bone defect. For such bone defect repair, autogenous bone, allogeneic bone and traditional artificial bone graft substitutes have many disadvantages. In recent years, a biomimetic mineralized collagen (MC) with similar composition and microstructu...

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Autores principales: Gao, Chong, Qiu, Zhi-Ye, Hou, Jian-Wen, Tian, Wei, Kou, Jian-Ming, Wang, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748453/
https://www.ncbi.nlm.nih.gov/pubmed/33365142
http://dx.doi.org/10.1093/rb/rbaa031
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author Gao, Chong
Qiu, Zhi-Ye
Hou, Jian-Wen
Tian, Wei
Kou, Jian-Ming
Wang, Xi
author_facet Gao, Chong
Qiu, Zhi-Ye
Hou, Jian-Wen
Tian, Wei
Kou, Jian-Ming
Wang, Xi
author_sort Gao, Chong
collection PubMed
description Curettage of benign bone tumor is a common cause for bone defect. For such bone defect repair, autogenous bone, allogeneic bone and traditional artificial bone graft substitutes have many disadvantages. In recent years, a biomimetic mineralized collagen (MC) with similar composition and microstructures to the natural bone matrix was developed and used for treating various bone defects. In this work, a retrospective study analyzed clinical outcomes of patients treated with curettage of benign bone tumors and bone grafting with MC, in comparison to another group treated with the same surgical method and autogenous bone. Lane–Sandhu X-ray score of the autogenous bone group was superior to the MC group at 1 month after the operation, but the two groups had no statistical difference at 6 and 12 months. The MC group was better in Musculoskeletal Tumor Society scoring at 1 and 6 months after the operation, and the two groups had no statistical difference at 12 month. Therefore, the MC performed not as good as autogenous bone in early stage of bone healing but achieved comparable outcomes in long-term follow-ups. Moreover, the MC has advantages in function recovery and avoided potential complications induced by harvesting autogenous bone.
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spelling pubmed-77484532020-12-22 Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors Gao, Chong Qiu, Zhi-Ye Hou, Jian-Wen Tian, Wei Kou, Jian-Ming Wang, Xi Regen Biomater Research Articles Curettage of benign bone tumor is a common cause for bone defect. For such bone defect repair, autogenous bone, allogeneic bone and traditional artificial bone graft substitutes have many disadvantages. In recent years, a biomimetic mineralized collagen (MC) with similar composition and microstructures to the natural bone matrix was developed and used for treating various bone defects. In this work, a retrospective study analyzed clinical outcomes of patients treated with curettage of benign bone tumors and bone grafting with MC, in comparison to another group treated with the same surgical method and autogenous bone. Lane–Sandhu X-ray score of the autogenous bone group was superior to the MC group at 1 month after the operation, but the two groups had no statistical difference at 6 and 12 months. The MC group was better in Musculoskeletal Tumor Society scoring at 1 and 6 months after the operation, and the two groups had no statistical difference at 12 month. Therefore, the MC performed not as good as autogenous bone in early stage of bone healing but achieved comparable outcomes in long-term follow-ups. Moreover, the MC has advantages in function recovery and avoided potential complications induced by harvesting autogenous bone. Oxford University Press 2020-12-15 /pmc/articles/PMC7748453/ /pubmed/33365142 http://dx.doi.org/10.1093/rb/rbaa031 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Gao, Chong
Qiu, Zhi-Ye
Hou, Jian-Wen
Tian, Wei
Kou, Jian-Ming
Wang, Xi
Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors
title Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors
title_full Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors
title_fullStr Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors
title_full_unstemmed Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors
title_short Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors
title_sort clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748453/
https://www.ncbi.nlm.nih.gov/pubmed/33365142
http://dx.doi.org/10.1093/rb/rbaa031
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