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An Overview of In Vitro, In Vivo, and Computational Techniques for Cancer-Associated Angiogenesis Studies

Angiogenesis is a crucial area in scientific research because it involves many important physiological and pathological processes. Indeed, angiogenesis is critical for normal physiological processes, including wound healing and embryonic development, as well as being a component of many disorders, s...

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Autores principales: Rahman, Heshu Sulaiman, Tan, Bee Ling, Othman, Hemn Hassan, Chartrand, Max Stanley, Pathak, Yashwant, Mohan, Syam, Abdullah, Rasedee, Alitheen, Noorjahan Banu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748901/
https://www.ncbi.nlm.nih.gov/pubmed/33381591
http://dx.doi.org/10.1155/2020/8857428
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author Rahman, Heshu Sulaiman
Tan, Bee Ling
Othman, Hemn Hassan
Chartrand, Max Stanley
Pathak, Yashwant
Mohan, Syam
Abdullah, Rasedee
Alitheen, Noorjahan Banu
author_facet Rahman, Heshu Sulaiman
Tan, Bee Ling
Othman, Hemn Hassan
Chartrand, Max Stanley
Pathak, Yashwant
Mohan, Syam
Abdullah, Rasedee
Alitheen, Noorjahan Banu
author_sort Rahman, Heshu Sulaiman
collection PubMed
description Angiogenesis is a crucial area in scientific research because it involves many important physiological and pathological processes. Indeed, angiogenesis is critical for normal physiological processes, including wound healing and embryonic development, as well as being a component of many disorders, such as rheumatoid arthritis, obesity, and diabetic retinopathies. Investigations of angiogenic mechanisms require assays that can activate the critical steps of angiogenesis as well as provide a tool for assessing the efficacy of therapeutic agents. Thus, angiogenesis assays are key tools for studying the mechanisms of angiogenesis and identifying the potential therapeutic strategies to modulate neovascularization. However, the regulation of angiogenesis is highly complex and not fully understood. Difficulties in assessing the regulators of angiogenic response have necessitated the development of an alternative approach. In this paper, we review the standard models for the study of tumor angiogenesis on the macroscopic scale that include in vitro, in vivo, and computational models. We also highlight the differences in several modeling approaches and describe key advances in understanding the computational models that contributed to the knowledge base of the field.
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spelling pubmed-77489012020-12-29 An Overview of In Vitro, In Vivo, and Computational Techniques for Cancer-Associated Angiogenesis Studies Rahman, Heshu Sulaiman Tan, Bee Ling Othman, Hemn Hassan Chartrand, Max Stanley Pathak, Yashwant Mohan, Syam Abdullah, Rasedee Alitheen, Noorjahan Banu Biomed Res Int Review Article Angiogenesis is a crucial area in scientific research because it involves many important physiological and pathological processes. Indeed, angiogenesis is critical for normal physiological processes, including wound healing and embryonic development, as well as being a component of many disorders, such as rheumatoid arthritis, obesity, and diabetic retinopathies. Investigations of angiogenic mechanisms require assays that can activate the critical steps of angiogenesis as well as provide a tool for assessing the efficacy of therapeutic agents. Thus, angiogenesis assays are key tools for studying the mechanisms of angiogenesis and identifying the potential therapeutic strategies to modulate neovascularization. However, the regulation of angiogenesis is highly complex and not fully understood. Difficulties in assessing the regulators of angiogenic response have necessitated the development of an alternative approach. In this paper, we review the standard models for the study of tumor angiogenesis on the macroscopic scale that include in vitro, in vivo, and computational models. We also highlight the differences in several modeling approaches and describe key advances in understanding the computational models that contributed to the knowledge base of the field. Hindawi 2020-12-10 /pmc/articles/PMC7748901/ /pubmed/33381591 http://dx.doi.org/10.1155/2020/8857428 Text en Copyright © 2020 Heshu Sulaiman Rahman et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rahman, Heshu Sulaiman
Tan, Bee Ling
Othman, Hemn Hassan
Chartrand, Max Stanley
Pathak, Yashwant
Mohan, Syam
Abdullah, Rasedee
Alitheen, Noorjahan Banu
An Overview of In Vitro, In Vivo, and Computational Techniques for Cancer-Associated Angiogenesis Studies
title An Overview of In Vitro, In Vivo, and Computational Techniques for Cancer-Associated Angiogenesis Studies
title_full An Overview of In Vitro, In Vivo, and Computational Techniques for Cancer-Associated Angiogenesis Studies
title_fullStr An Overview of In Vitro, In Vivo, and Computational Techniques for Cancer-Associated Angiogenesis Studies
title_full_unstemmed An Overview of In Vitro, In Vivo, and Computational Techniques for Cancer-Associated Angiogenesis Studies
title_short An Overview of In Vitro, In Vivo, and Computational Techniques for Cancer-Associated Angiogenesis Studies
title_sort overview of in vitro, in vivo, and computational techniques for cancer-associated angiogenesis studies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748901/
https://www.ncbi.nlm.nih.gov/pubmed/33381591
http://dx.doi.org/10.1155/2020/8857428
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