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The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse
The risk of relapsing into depression after stopping antidepressants is high, but no established predictors exist. Resting-state functional magnetic resonance imaging (rsfMRI) measures may help predict relapse and identify the mechanisms by which relapses occur. rsfMRI data were acquired from health...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749105/ https://www.ncbi.nlm.nih.gov/pubmed/33339879 http://dx.doi.org/10.1038/s41598-020-79170-9 |
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author | Berwian, Isabel M. Wenzel, Julia G. Kuehn, Leonie Schnuerer, Inga Kasper, Lars Veer, Ilya M. Seifritz, Erich Stephan, Klaas E. Walter, Henrik Huys, Quentin J. M. |
author_facet | Berwian, Isabel M. Wenzel, Julia G. Kuehn, Leonie Schnuerer, Inga Kasper, Lars Veer, Ilya M. Seifritz, Erich Stephan, Klaas E. Walter, Henrik Huys, Quentin J. M. |
author_sort | Berwian, Isabel M. |
collection | PubMed |
description | The risk of relapsing into depression after stopping antidepressants is high, but no established predictors exist. Resting-state functional magnetic resonance imaging (rsfMRI) measures may help predict relapse and identify the mechanisms by which relapses occur. rsfMRI data were acquired from healthy controls and from patients with remitted major depressive disorder on antidepressants. Patients were assessed a second time either before or after discontinuation of the antidepressant, and followed up for six months to assess relapse. A seed-based functional connectivity analysis was conducted focusing on the left subgenual anterior cingulate cortex and left posterior cingulate cortex. Seeds in the amygdala and dorsolateral prefrontal cortex were explored. 44 healthy controls (age: 33.8 (10.5), 73% female) and 84 patients (age: 34.23 (10.8), 80% female) were included in the analysis. 29 patients went on to relapse and 38 remained well. The seed-based analysis showed that discontinuation resulted in an increased functional connectivity between the right dorsolateral prefrontal cortex and the parietal cortex in non-relapsers. In an exploratory analysis, this functional connectivity predicted relapse risk with a balanced accuracy of 0.86. Further seed-based analyses, however, failed to reveal differences in functional connectivity between patients and controls, between relapsers and non-relapsers before discontinuation and changes due to discontinuation independent of relapse. In conclusion, changes in the connectivity between the dorsolateral prefrontal cortex and the posterior default mode network were associated with and predictive of relapse after open-label antidepressant discontinuation. This finding requires replication in a larger dataset. |
format | Online Article Text |
id | pubmed-7749105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77491052020-12-22 The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse Berwian, Isabel M. Wenzel, Julia G. Kuehn, Leonie Schnuerer, Inga Kasper, Lars Veer, Ilya M. Seifritz, Erich Stephan, Klaas E. Walter, Henrik Huys, Quentin J. M. Sci Rep Article The risk of relapsing into depression after stopping antidepressants is high, but no established predictors exist. Resting-state functional magnetic resonance imaging (rsfMRI) measures may help predict relapse and identify the mechanisms by which relapses occur. rsfMRI data were acquired from healthy controls and from patients with remitted major depressive disorder on antidepressants. Patients were assessed a second time either before or after discontinuation of the antidepressant, and followed up for six months to assess relapse. A seed-based functional connectivity analysis was conducted focusing on the left subgenual anterior cingulate cortex and left posterior cingulate cortex. Seeds in the amygdala and dorsolateral prefrontal cortex were explored. 44 healthy controls (age: 33.8 (10.5), 73% female) and 84 patients (age: 34.23 (10.8), 80% female) were included in the analysis. 29 patients went on to relapse and 38 remained well. The seed-based analysis showed that discontinuation resulted in an increased functional connectivity between the right dorsolateral prefrontal cortex and the parietal cortex in non-relapsers. In an exploratory analysis, this functional connectivity predicted relapse risk with a balanced accuracy of 0.86. Further seed-based analyses, however, failed to reveal differences in functional connectivity between patients and controls, between relapsers and non-relapsers before discontinuation and changes due to discontinuation independent of relapse. In conclusion, changes in the connectivity between the dorsolateral prefrontal cortex and the posterior default mode network were associated with and predictive of relapse after open-label antidepressant discontinuation. This finding requires replication in a larger dataset. Nature Publishing Group UK 2020-12-18 /pmc/articles/PMC7749105/ /pubmed/33339879 http://dx.doi.org/10.1038/s41598-020-79170-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Berwian, Isabel M. Wenzel, Julia G. Kuehn, Leonie Schnuerer, Inga Kasper, Lars Veer, Ilya M. Seifritz, Erich Stephan, Klaas E. Walter, Henrik Huys, Quentin J. M. The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse |
title | The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse |
title_full | The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse |
title_fullStr | The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse |
title_full_unstemmed | The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse |
title_short | The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse |
title_sort | relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749105/ https://www.ncbi.nlm.nih.gov/pubmed/33339879 http://dx.doi.org/10.1038/s41598-020-79170-9 |
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