Novel use of a chemically modified siRNA for robust and sustainable in vivo gene silencing in the retina

Despite efficient and specific in vitro knockdown, more reliable and convenient methods for in vivo knockdown of target genes remain to be developed particularly for retinal research. Using commercially available and chemically modified siRNA so-called Accell siRNA, we established a novel in vivo ge...

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Detalles Bibliográficos
Autores principales: Taniguchi, Takazumi, Endo, Ken-ichi, Tanioka, Hidetoshi, Sasaoka, Masaaki, Tashiro, Kei, Kinoshita, Shigeru, Kageyama, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749170/
https://www.ncbi.nlm.nih.gov/pubmed/33339841
http://dx.doi.org/10.1038/s41598-020-79242-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749170/
https://www.ncbi.nlm.nih.gov/pubmed/33339841
http://dx.doi.org/10.1038/s41598-020-79242-w

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