Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients

Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who underwent hepatic sur...

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Detalles Bibliográficos
Autores principales: Bohlok, Ali, Vermeulen, Peter, Leduc, Sophia, Latacz, Emily, Botzenhart, Lara, Richard, François, De Schepper, Maxim, Geukens, Tatjana, Lucidi, Valerio, Ignatiadis, Michail, Aftimos, Philippe, Sotiriou, Christos, Piccart, Martine, Hendlisz, Alain, Van Laere, Steven, Dirix, Luc, Noël, Jean-Christophe, Biganzoli, Elia, Larsimont, Denis, Desmedt, Christine, Donckier, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749172/
https://www.ncbi.nlm.nih.gov/pubmed/33339824
http://dx.doi.org/10.1038/s41523-020-00209-1
Descripción
Sumario:Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who underwent hepatic surgery. Survival analyses showed that the presence of a desmoplastic HGP in the liver metastases (a rim of fibrous tissue separating cancer cells from the liver parenchyma, present in 20 (56%) patients) is independently associated with favorable progression-free and overall survival when compared with the replacement HGP (cancer cells growing into the liver parenchyma, present in 16 (44%) patients).

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