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Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients
Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who underwent hepatic sur...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749172/ https://www.ncbi.nlm.nih.gov/pubmed/33339824 http://dx.doi.org/10.1038/s41523-020-00209-1 |
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| author | Bohlok, Ali Vermeulen, Peter Leduc, Sophia Latacz, Emily Botzenhart, Lara Richard, François De Schepper, Maxim Geukens, Tatjana Lucidi, Valerio Ignatiadis, Michail Aftimos, Philippe Sotiriou, Christos Piccart, Martine Hendlisz, Alain Van Laere, Steven Dirix, Luc Noël, Jean-Christophe Biganzoli, Elia Larsimont, Denis Desmedt, Christine Donckier, Vincent |
| author_facet | Bohlok, Ali Vermeulen, Peter Leduc, Sophia Latacz, Emily Botzenhart, Lara Richard, François De Schepper, Maxim Geukens, Tatjana Lucidi, Valerio Ignatiadis, Michail Aftimos, Philippe Sotiriou, Christos Piccart, Martine Hendlisz, Alain Van Laere, Steven Dirix, Luc Noël, Jean-Christophe Biganzoli, Elia Larsimont, Denis Desmedt, Christine Donckier, Vincent |
| author_sort | Bohlok, Ali |
| collection | PubMed |
| description | Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who underwent hepatic surgery. Survival analyses showed that the presence of a desmoplastic HGP in the liver metastases (a rim of fibrous tissue separating cancer cells from the liver parenchyma, present in 20 (56%) patients) is independently associated with favorable progression-free and overall survival when compared with the replacement HGP (cancer cells growing into the liver parenchyma, present in 16 (44%) patients). |
| format | Online Article Text |
| id | pubmed-7749172 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77491722020-12-21 Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients Bohlok, Ali Vermeulen, Peter Leduc, Sophia Latacz, Emily Botzenhart, Lara Richard, François De Schepper, Maxim Geukens, Tatjana Lucidi, Valerio Ignatiadis, Michail Aftimos, Philippe Sotiriou, Christos Piccart, Martine Hendlisz, Alain Van Laere, Steven Dirix, Luc Noël, Jean-Christophe Biganzoli, Elia Larsimont, Denis Desmedt, Christine Donckier, Vincent NPJ Breast Cancer Brief Communication Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who underwent hepatic surgery. Survival analyses showed that the presence of a desmoplastic HGP in the liver metastases (a rim of fibrous tissue separating cancer cells from the liver parenchyma, present in 20 (56%) patients) is independently associated with favorable progression-free and overall survival when compared with the replacement HGP (cancer cells growing into the liver parenchyma, present in 16 (44%) patients). Nature Publishing Group UK 2020-12-18 /pmc/articles/PMC7749172/ /pubmed/33339824 http://dx.doi.org/10.1038/s41523-020-00209-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Brief Communication Bohlok, Ali Vermeulen, Peter Leduc, Sophia Latacz, Emily Botzenhart, Lara Richard, François De Schepper, Maxim Geukens, Tatjana Lucidi, Valerio Ignatiadis, Michail Aftimos, Philippe Sotiriou, Christos Piccart, Martine Hendlisz, Alain Van Laere, Steven Dirix, Luc Noël, Jean-Christophe Biganzoli, Elia Larsimont, Denis Desmedt, Christine Donckier, Vincent Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients |
| title | Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients |
| title_full | Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients |
| title_fullStr | Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients |
| title_full_unstemmed | Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients |
| title_short | Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients |
| title_sort | association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749172/ https://www.ncbi.nlm.nih.gov/pubmed/33339824 http://dx.doi.org/10.1038/s41523-020-00209-1 |
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