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Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization

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Amyloid precursor protein (APP) cleavage by the β-secretase produces the C99 transmembrane (TM) protein, which contains three dimerization-inducing Gly-x-x-x-Gly motifs. We demonstrate that dimeric C99 TM orientations regulate the precise cleavage lines by γ-secretase. Of all possible dimeric orient...

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Detalles Bibliográficos
Autores principales:	Perrin, Florian, Papadopoulos, Nicolas, Suelves, Nuria, Opsomer, Rémi, Vadukul, Devkee M., Vrancx, Céline, Smith, Steven O., Vertommen, Didier, Kienlen-Campard, Pascal, Constantinescu, Stefan N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749410/ https://www.ncbi.nlm.nih.gov/pubmed/33367225 http://dx.doi.org/10.1016/j.isci.2020.101887

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