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High-throughput quantification of ochronotic pigment formation in Escherichia coli to evaluate the potency of human 4-hydroxyphenylpyruvate dioxygenase inhibitors in multi-well format

4-hydroxyphenylpyruvate dioxygenase (HPD) is a key enzyme in the catabolism of tyrosine and therefore of great importance as a drug target to treat tyrosine-related inherited metabolic disorders (TIMD). Inhibition of this enzyme is therapeutically applied to prevent accumulation of toxic metabolites...

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Detalles Bibliográficos
Autores principales:	Neuckermans, Jessie, Lequeue, Sien, Mertens, Alan, Branson, Steven, Schwaneberg, Ulrich, De Kock, Joery
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Method Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749435/ https://www.ncbi.nlm.nih.gov/pubmed/33365261 http://dx.doi.org/10.1016/j.mex.2020.101181

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