Cargando…

Small molecules to prevent the neurodegeneration caused by α-synuclein aggregation

Detalles Bibliográficos
Autores principales:	Peña-Díaz, Samuel, Pujols, Jordi, Ventura, Salvador
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2020
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749473/ https://www.ncbi.nlm.nih.gov/pubmed/32594046 http://dx.doi.org/10.4103/1673-5374.284993

Ejemplares similares

Small molecules to target tau amyloid aggregation
por: Manglano-Artuñedo, Zoe, et al.
Publicado: (2023)

Inducing α-synuclein compaction: a new strategy for inhibiting α-synuclein aggregation?
por: Pinheiro, Francisca, et al.
Publicado: (2019)

The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains
por: Peña-Díaz, Samuel, et al.
Publicado: (2022)

Development of Small Molecules Targeting α-Synuclein Aggregation: A Promising Strategy to Treat Parkinson’s Disease
por: Peña-Díaz, Samuel, et al.
Publicado: (2023)

ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization
por: Peña-Díaz, Samuel, et al.
Publicado: (2019)

One ring is sufficient to inhibit α-synuclein aggregation
por: Peña-Díaz, Samuel, et al.
Publicado: (2021)

High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors
por: Pujols, Jordi, et al.
Publicado: (2017)

Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson’s disease
por: Vittorio, Serena, et al.
Publicado: (2020)

Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm
por: Peña-Díaz, Samuel, et al.
Publicado: (2020)

α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
por: Santos, Jaime, et al.
Publicado: (2021)

Ligand-Based Discovery of a Small Molecule as Inhibitor of α-Synuclein Amyloid Formation
por: De Luca, Laura, et al.
Publicado: (2022)

Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity
por: Carija, Anita, et al.
Publicado: (2019)

Optimization of a small molecule inhibitor of secondary nucleation in α-synuclein aggregation
por: Staats, Roxine, et al.
Publicado: (2023)

Catecholamines and Neurodegeneration in Parkinson’s Disease—From Diagnostic Marker to Aggregations of α-Synuclein
por: Sawada, Hideyuki, et al.
Publicado: (2013)

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration
por: Davis, Marie Y., et al.
Publicado: (2016)

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates
por: Chia, Sean, et al.
Publicado: (2022)

Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation
por: Rosado-Ramos, Rita, et al.
Publicado: (2021)

An α-synuclein decoy peptide prevents cytotoxic α-synuclein aggregation caused by fatty acid binding protein 3
por: Fukui, Naoya, et al.
Publicado: (2021)

Neurodegeneration and the ordered assembly of α-synuclein
por: Spillantini, Maria Grazia, et al.
Publicado: (2017)

Novel Mannitol-Based Small Molecules for Inhibiting Aggregation of α-Synuclein Amyloids in Parkinson's Disease
por: Paul, Ashim, et al.
Publicado: (2019)

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation
por: Scheibe, Christian, et al.
Publicado: (2021)

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila
por: Bridi, Jessika C, et al.
Publicado: (2021)

Drug Targeting of α-Synuclein Oligomerization in Synucleinopathies
por: Outeiro, Tiago Fleming, et al.
Publicado: (2008)

Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons
por: Tourville, Aurore, et al.
Publicado: (2022)

A small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson’s disease
por: Peng, Ye, et al.
Publicado: (2023)

Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
por: Staats, Roxine, et al.
Publicado: (2020)

The Janus face of N-terminal lysines in α-synuclein
por: Uceda, Ana Belén, et al.
Publicado: (2020)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

Monitoring α-synuclein aggregation
por: Estaun-Panzano, Juan, et al.
Publicado: (2023)

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
por: Tran, Hien T., et al.
Publicado: (2014)

Alpha-synuclein in cutaneous small nerve fibers
por: Siepmann, Timo, et al.
Publicado: (2016)

Computational prediction of protein aggregation: Advances in proteomics, conformation-specific algorithms and biotechnological applications
por: Santos, Jaime, et al.
Publicado: (2020)

Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?
por: Pozo Devoto, Victorio M., et al.
Publicado: (2017)

Molecular Basis of Small-Molecule Binding to α-Synuclein
por: Robustelli, Paul, et al.
Publicado: (2022)

Targeted proteolytic products of τ and α-synuclein in neurodegeneration
por: Xia, Yuxing, et al.
Publicado: (2021)

Acceleration of α-Synuclein Aggregation by Exosomes
por: Grey, Marie, et al.
Publicado: (2015)

Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates
por: Acuña, Leonardo, et al.
Publicado: (2019)

Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
por: Emin, Derya, et al.
Publicado: (2022)

Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation
por: Vieira, Bruno Di Marco, et al.
Publicado: (2015)

Novel perspectives for neurodegeneration prevention: effects of bioactive polyphenols
por: Crispi, Stefania, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vnbpk71rca5tmjete577f1l9v8