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Insulin-like growth factor 1 partially rescues early developmental defects caused by SHANK2 knockdown in human neurons

SHANK2 is a scaffold protein that serves as a protein anchor at the postsynaptic density in neurons. Genetic variants of SHANK2 are strongly associated with synaptic dysfunction and the pathophysiology of autism spectrum disorder. Recent studies indicate that early neuronal developmental defects pla...

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Detalles Bibliográficos
Autores principales:	Chen, Shu-Ting, Lai, Wan-Jing, Zhang, Wei-Jia, Chen, Qing-Pei, Zhou, Li-Bing, So, Kwok-Fai, Shi, Ling-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749486/ https://www.ncbi.nlm.nih.gov/pubmed/32594058 http://dx.doi.org/10.4103/1673-5374.285002

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William Frederick Shanks
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