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Elevated homocysteine, as a biomarker of cardiac injury, in panic disorder patients due to oxidative stress

BACKGROUND AND OBJECTIVE: Patients with panic disorder (PD) suffer from elevated oxidative stress as a consequence of serotonin metabolism disorder. These patients have elevated serotonin concentration and catabolism of serotonin via monoamine oxidase. The aim of the present study was to evaluate se...

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Autores principales: Aghayan, Seyed Shahrokh, Farajzadeh, Asghar, Bagheri‐Hosseinabadi, Zahra, Fadaei, Homeyra, Yarmohammadi, Maryam, Jafarisani, Moslem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749574/
https://www.ncbi.nlm.nih.gov/pubmed/32969203
http://dx.doi.org/10.1002/brb3.1851
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author Aghayan, Seyed Shahrokh
Farajzadeh, Asghar
Bagheri‐Hosseinabadi, Zahra
Fadaei, Homeyra
Yarmohammadi, Maryam
Jafarisani, Moslem
author_facet Aghayan, Seyed Shahrokh
Farajzadeh, Asghar
Bagheri‐Hosseinabadi, Zahra
Fadaei, Homeyra
Yarmohammadi, Maryam
Jafarisani, Moslem
author_sort Aghayan, Seyed Shahrokh
collection PubMed
description BACKGROUND AND OBJECTIVE: Patients with panic disorder (PD) suffer from elevated oxidative stress as a consequence of serotonin metabolism disorder. These patients have elevated serotonin concentration and catabolism of serotonin via monoamine oxidase. The aim of the present study was to evaluate serum homocysteine concentration and its relationship with oxidative stress level in PD patients, regarding homocysteine as a diagnostic biomarker of heart disease. MATERIALS & METHOD: Sixty patients with PD according to the DSM‐5 diagnostic criteria for a panic attack and 60 healthy individuals were included in the present study. Peripheral venous blood samples were taken from patients. Erythrocytes and serum were separated from blood, and RBC hemolysates were prepared to investigate oxidative stress indices including glutathione and glutathione peroxidase. Serum homocysteine and carbonyl groups concentrations were measured in all samples. Data were analyzed using ANOVA, and p < .05 was considered significant. RESULTS: Results showed that serum carbonyl groups concentration was significantly higher in patients with PD than in healthy individuals (p < .001). The results also indicated decreased serum glutathione concentration and glutathione peroxidase activity in patients (p < .003). In addition, elevated homocysteine concentration in PD patients serum was observed during the present study (p < .003). CONCLUSION: Our findings support that patients with PD experience higher levels of oxidative stress, due to impaired serotonin metabolism, which is related to the prognosis of heart disease in these patients.
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spelling pubmed-77495742020-12-23 Elevated homocysteine, as a biomarker of cardiac injury, in panic disorder patients due to oxidative stress Aghayan, Seyed Shahrokh Farajzadeh, Asghar Bagheri‐Hosseinabadi, Zahra Fadaei, Homeyra Yarmohammadi, Maryam Jafarisani, Moslem Brain Behav Original Research BACKGROUND AND OBJECTIVE: Patients with panic disorder (PD) suffer from elevated oxidative stress as a consequence of serotonin metabolism disorder. These patients have elevated serotonin concentration and catabolism of serotonin via monoamine oxidase. The aim of the present study was to evaluate serum homocysteine concentration and its relationship with oxidative stress level in PD patients, regarding homocysteine as a diagnostic biomarker of heart disease. MATERIALS & METHOD: Sixty patients with PD according to the DSM‐5 diagnostic criteria for a panic attack and 60 healthy individuals were included in the present study. Peripheral venous blood samples were taken from patients. Erythrocytes and serum were separated from blood, and RBC hemolysates were prepared to investigate oxidative stress indices including glutathione and glutathione peroxidase. Serum homocysteine and carbonyl groups concentrations were measured in all samples. Data were analyzed using ANOVA, and p < .05 was considered significant. RESULTS: Results showed that serum carbonyl groups concentration was significantly higher in patients with PD than in healthy individuals (p < .001). The results also indicated decreased serum glutathione concentration and glutathione peroxidase activity in patients (p < .003). In addition, elevated homocysteine concentration in PD patients serum was observed during the present study (p < .003). CONCLUSION: Our findings support that patients with PD experience higher levels of oxidative stress, due to impaired serotonin metabolism, which is related to the prognosis of heart disease in these patients. John Wiley and Sons Inc. 2020-09-23 /pmc/articles/PMC7749574/ /pubmed/32969203 http://dx.doi.org/10.1002/brb3.1851 Text en © 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Aghayan, Seyed Shahrokh
Farajzadeh, Asghar
Bagheri‐Hosseinabadi, Zahra
Fadaei, Homeyra
Yarmohammadi, Maryam
Jafarisani, Moslem
Elevated homocysteine, as a biomarker of cardiac injury, in panic disorder patients due to oxidative stress
title Elevated homocysteine, as a biomarker of cardiac injury, in panic disorder patients due to oxidative stress
title_full Elevated homocysteine, as a biomarker of cardiac injury, in panic disorder patients due to oxidative stress
title_fullStr Elevated homocysteine, as a biomarker of cardiac injury, in panic disorder patients due to oxidative stress
title_full_unstemmed Elevated homocysteine, as a biomarker of cardiac injury, in panic disorder patients due to oxidative stress
title_short Elevated homocysteine, as a biomarker of cardiac injury, in panic disorder patients due to oxidative stress
title_sort elevated homocysteine, as a biomarker of cardiac injury, in panic disorder patients due to oxidative stress
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749574/
https://www.ncbi.nlm.nih.gov/pubmed/32969203
http://dx.doi.org/10.1002/brb3.1851
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