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Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea
OBJECTIVES: Concerns have been expressed that some drugs may increase susceptibility to SARS-CoV-2 infection. In contrast, other drugs have generated interest as potential therapeutic agents. METHODS: All adults aged ≥18 years who were tested for COVID-19 were included. Exposure was defined as a pre...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749643/ https://www.ncbi.nlm.nih.gov/pubmed/33352326 http://dx.doi.org/10.1016/j.ijid.2020.12.041 |
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author | Huh, Kyungmin Ji, Wonjun Kang, Minsun Hong, Jinwook Bae, Gi Hwan Lee, Rugyeom Na, Yewon Jung, Jaehun |
author_facet | Huh, Kyungmin Ji, Wonjun Kang, Minsun Hong, Jinwook Bae, Gi Hwan Lee, Rugyeom Na, Yewon Jung, Jaehun |
author_sort | Huh, Kyungmin |
collection | PubMed |
description | OBJECTIVES: Concerns have been expressed that some drugs may increase susceptibility to SARS-CoV-2 infection. In contrast, other drugs have generated interest as potential therapeutic agents. METHODS: All adults aged ≥18 years who were tested for COVID-19 were included. Exposure was defined as a prescription of study drugs which would have been continued until 7 days prior to test for COVID-19 or later. The outcome measures were the diagnosis of COVID-19 and severe COVID-19. Disease risk score matching and multiple logistic regression was used. RESULTS: Matched claims and testing results were available for 219,961 subjects, of whom 7,341 (3.34%) were diagnosed with COVID-19. Patients were matched to 36,705 controls, and the subset of 878 patients of severe COVID-19 also matched with 1,927 mild-to-moderate patients. Angiotensin receptor blockers were not associated with either the diagnosis of COVID-19 (adjusted OR [aOR], 1.02; 95% confidence interval [CI], 0.90–1.15) or severe disease (aOR, 1.11; 95% CI, 0.87–1.42). The use of hydroxychloroquine was not associated with a lower risk for COVID-19 (aOR, 0.94; 95% CI, 0.53–1.66) or severe disease (aOR, 3.51; 95% CI, 0.76–16.22). CONCLUSIONS: In this national claims data-based case-control study, no commonly prescribed medications were associated with risk of COVID-19 infection or COVID-19 severity. |
format | Online Article Text |
id | pubmed-7749643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77496432020-12-21 Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea Huh, Kyungmin Ji, Wonjun Kang, Minsun Hong, Jinwook Bae, Gi Hwan Lee, Rugyeom Na, Yewon Jung, Jaehun Int J Infect Dis Article OBJECTIVES: Concerns have been expressed that some drugs may increase susceptibility to SARS-CoV-2 infection. In contrast, other drugs have generated interest as potential therapeutic agents. METHODS: All adults aged ≥18 years who were tested for COVID-19 were included. Exposure was defined as a prescription of study drugs which would have been continued until 7 days prior to test for COVID-19 or later. The outcome measures were the diagnosis of COVID-19 and severe COVID-19. Disease risk score matching and multiple logistic regression was used. RESULTS: Matched claims and testing results were available for 219,961 subjects, of whom 7,341 (3.34%) were diagnosed with COVID-19. Patients were matched to 36,705 controls, and the subset of 878 patients of severe COVID-19 also matched with 1,927 mild-to-moderate patients. Angiotensin receptor blockers were not associated with either the diagnosis of COVID-19 (adjusted OR [aOR], 1.02; 95% confidence interval [CI], 0.90–1.15) or severe disease (aOR, 1.11; 95% CI, 0.87–1.42). The use of hydroxychloroquine was not associated with a lower risk for COVID-19 (aOR, 0.94; 95% CI, 0.53–1.66) or severe disease (aOR, 3.51; 95% CI, 0.76–16.22). CONCLUSIONS: In this national claims data-based case-control study, no commonly prescribed medications were associated with risk of COVID-19 infection or COVID-19 severity. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-03 2020-12-19 /pmc/articles/PMC7749643/ /pubmed/33352326 http://dx.doi.org/10.1016/j.ijid.2020.12.041 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Huh, Kyungmin Ji, Wonjun Kang, Minsun Hong, Jinwook Bae, Gi Hwan Lee, Rugyeom Na, Yewon Jung, Jaehun Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea |
title | Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea |
title_full | Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea |
title_fullStr | Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea |
title_full_unstemmed | Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea |
title_short | Association of prescribed medications with the risk of COVID-19 infection and severity among adults in South Korea |
title_sort | association of prescribed medications with the risk of covid-19 infection and severity among adults in south korea |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749643/ https://www.ncbi.nlm.nih.gov/pubmed/33352326 http://dx.doi.org/10.1016/j.ijid.2020.12.041 |
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