DNA vaccines against COVID-19: Perspectives and challenges

The coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is associated with several fatal cases worldwide. The rapid spread of this pathogen and the increasing number of cases highlight the urgent developmen...

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Autores principales: Silveira, Marcelle Moura, Moreira, Gustavo Marçal Schmidt Garcia, Mendonça, Marcelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749647/
https://www.ncbi.nlm.nih.gov/pubmed/33352173
http://dx.doi.org/10.1016/j.lfs.2020.118919
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author Silveira, Marcelle Moura
Moreira, Gustavo Marçal Schmidt Garcia
Mendonça, Marcelo
author_facet Silveira, Marcelle Moura
Moreira, Gustavo Marçal Schmidt Garcia
Mendonça, Marcelo
author_sort Silveira, Marcelle Moura
collection PubMed
description The coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is associated with several fatal cases worldwide. The rapid spread of this pathogen and the increasing number of cases highlight the urgent development of vaccines. Among the technologies available for vaccine development, DNA vaccination is a promising alternative to conventional vaccines. Since its discovery in the 1990s, it has been of great interest because of its ability to elicit both humoral and cellular immune responses while showing relevant advantages regarding producibility, stability, and storage. This review aimed to summarize the current knowledge and advancements on DNA vaccines against COVID-19, particularly those in clinical trials.
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spelling pubmed-77496472020-12-21 DNA vaccines against COVID-19: Perspectives and challenges Silveira, Marcelle Moura Moreira, Gustavo Marçal Schmidt Garcia Mendonça, Marcelo Life Sci Article The coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is associated with several fatal cases worldwide. The rapid spread of this pathogen and the increasing number of cases highlight the urgent development of vaccines. Among the technologies available for vaccine development, DNA vaccination is a promising alternative to conventional vaccines. Since its discovery in the 1990s, it has been of great interest because of its ability to elicit both humoral and cellular immune responses while showing relevant advantages regarding producibility, stability, and storage. This review aimed to summarize the current knowledge and advancements on DNA vaccines against COVID-19, particularly those in clinical trials. Published by Elsevier Inc. 2021-02-15 2020-12-19 /pmc/articles/PMC7749647/ /pubmed/33352173 http://dx.doi.org/10.1016/j.lfs.2020.118919 Text en © 2020 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Silveira, Marcelle Moura
Moreira, Gustavo Marçal Schmidt Garcia
Mendonça, Marcelo
DNA vaccines against COVID-19: Perspectives and challenges
title DNA vaccines against COVID-19: Perspectives and challenges
title_full DNA vaccines against COVID-19: Perspectives and challenges
title_fullStr DNA vaccines against COVID-19: Perspectives and challenges
title_full_unstemmed DNA vaccines against COVID-19: Perspectives and challenges
title_short DNA vaccines against COVID-19: Perspectives and challenges
title_sort dna vaccines against covid-19: perspectives and challenges
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749647/
https://www.ncbi.nlm.nih.gov/pubmed/33352173
http://dx.doi.org/10.1016/j.lfs.2020.118919
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