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β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response
Sepsis is characterized by a dysregulated immune response to infection characterized by an early hyperinflammatory and oxidative response followed by a subsequent immunosuppression phase. Although there have been some advances in the treatment of sepsis, mortality rates remain high, urging for the s...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749764/ https://www.ncbi.nlm.nih.gov/pubmed/33381269 http://dx.doi.org/10.1155/2020/8820651 |
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author | de B. Oliveira, Ana L. Navegantes-Lima, Kely C. Monteiro, Valter V. S. Quadros, Lucas B. G. de Oliveira, Juliana P. dos Santos, Sávio M. de A. Pontes, Anna C. A. Dorneles, Gilson P. Romão, Pedro R. T. Júnior, Luiz C. R. de Oliveira, Alaíde B. Monteiro, Marta C. |
author_facet | de B. Oliveira, Ana L. Navegantes-Lima, Kely C. Monteiro, Valter V. S. Quadros, Lucas B. G. de Oliveira, Juliana P. dos Santos, Sávio M. de A. Pontes, Anna C. A. Dorneles, Gilson P. Romão, Pedro R. T. Júnior, Luiz C. R. de Oliveira, Alaíde B. Monteiro, Marta C. |
author_sort | de B. Oliveira, Ana L. |
collection | PubMed |
description | Sepsis is characterized by a dysregulated immune response to infection characterized by an early hyperinflammatory and oxidative response followed by a subsequent immunosuppression phase. Although there have been some advances in the treatment of sepsis, mortality rates remain high, urging for the search of new therapies. β-Lapachone (β-Lap) is a natural compound obtained from Tabebuia avellanedae Lorentz ex Griseb. with several pharmacological properties including bactericidal, anti-inflammatory, and antioxidant activity. Thus, the aim of this study was to evaluate the effects of β-Lap in a mouse sepsis model. To this, we tested two therapeutic protocols in mice submitted to cecal ligation and puncture- (CLP-) induced sepsis. First, we found that in pretreated animals, β-Lap reduced the systemic inflammatory response and improved bacterial clearance and mouse survival. Moreover, β-Lap also decreased lipid peroxidation and increased the total antioxidant capacity in the serum and peritoneal cavity of septic animals. In the model of severe sepsis, the posttreatment with β-Lap was able to increase the survival of animals and maintain the antioxidant defense function. In conclusion, the β-Lap was able to increase the survival of septic animals by a mechanism involving immunomodulatory and antioxidant protective effects. |
format | Online Article Text |
id | pubmed-7749764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-77497642020-12-29 β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response de B. Oliveira, Ana L. Navegantes-Lima, Kely C. Monteiro, Valter V. S. Quadros, Lucas B. G. de Oliveira, Juliana P. dos Santos, Sávio M. de A. Pontes, Anna C. A. Dorneles, Gilson P. Romão, Pedro R. T. Júnior, Luiz C. R. de Oliveira, Alaíde B. Monteiro, Marta C. Oxid Med Cell Longev Research Article Sepsis is characterized by a dysregulated immune response to infection characterized by an early hyperinflammatory and oxidative response followed by a subsequent immunosuppression phase. Although there have been some advances in the treatment of sepsis, mortality rates remain high, urging for the search of new therapies. β-Lapachone (β-Lap) is a natural compound obtained from Tabebuia avellanedae Lorentz ex Griseb. with several pharmacological properties including bactericidal, anti-inflammatory, and antioxidant activity. Thus, the aim of this study was to evaluate the effects of β-Lap in a mouse sepsis model. To this, we tested two therapeutic protocols in mice submitted to cecal ligation and puncture- (CLP-) induced sepsis. First, we found that in pretreated animals, β-Lap reduced the systemic inflammatory response and improved bacterial clearance and mouse survival. Moreover, β-Lap also decreased lipid peroxidation and increased the total antioxidant capacity in the serum and peritoneal cavity of septic animals. In the model of severe sepsis, the posttreatment with β-Lap was able to increase the survival of animals and maintain the antioxidant defense function. In conclusion, the β-Lap was able to increase the survival of septic animals by a mechanism involving immunomodulatory and antioxidant protective effects. Hindawi 2020-12-12 /pmc/articles/PMC7749764/ /pubmed/33381269 http://dx.doi.org/10.1155/2020/8820651 Text en Copyright © 2020 Ana L. de B. Oliveira et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article de B. Oliveira, Ana L. Navegantes-Lima, Kely C. Monteiro, Valter V. S. Quadros, Lucas B. G. de Oliveira, Juliana P. dos Santos, Sávio M. de A. Pontes, Anna C. A. Dorneles, Gilson P. Romão, Pedro R. T. Júnior, Luiz C. R. de Oliveira, Alaíde B. Monteiro, Marta C. β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response |
title |
β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response |
title_full |
β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response |
title_fullStr |
β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response |
title_full_unstemmed |
β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response |
title_short |
β-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response |
title_sort | β-lapachone increases survival of septic mice by regulating inflammatory and oxidative response |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749764/ https://www.ncbi.nlm.nih.gov/pubmed/33381269 http://dx.doi.org/10.1155/2020/8820651 |
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