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Cypermethrin poisoning manifesting with prolonged bradycardia: A case report
Pyrethrins and their synthetic derivatives known as pyrethroids are highly effective insecticides used worldwide in the agricultural fields and households. Cypermethrin is a type II pyrethroid which acts primarily by delaying the closure of voltage-sensitive sodium channels at higher concentrations....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750177/ https://www.ncbi.nlm.nih.gov/pubmed/33364178 http://dx.doi.org/10.1016/j.toxrep.2020.12.005 |
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author | Shilpakar, Olita Karki, Bipin |
author_facet | Shilpakar, Olita Karki, Bipin |
author_sort | Shilpakar, Olita |
collection | PubMed |
description | Pyrethrins and their synthetic derivatives known as pyrethroids are highly effective insecticides used worldwide in the agricultural fields and households. Cypermethrin is a type II pyrethroid which acts primarily by delaying the closure of voltage-sensitive sodium channels at higher concentrations. Its toxicity in humans occur due to accidental or intentional exposure through inhalation, skin contact or via ingestion. Acute oral intoxication of cypermethrin commonly manifests with neurotoxic and gastrointestinal effects in humans. Cardiotoxic effects following ingestion of this compound have occurred in a few cases but underreported to date. This case highlights a case of intentional cypermethrin poisoning with acute effects in the form of prolonged bradycardia symptomatically managed with a muscarinic antagonist like atropine sulphate. |
format | Online Article Text |
id | pubmed-7750177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-77501772020-12-23 Cypermethrin poisoning manifesting with prolonged bradycardia: A case report Shilpakar, Olita Karki, Bipin Toxicol Rep Regular Article Pyrethrins and their synthetic derivatives known as pyrethroids are highly effective insecticides used worldwide in the agricultural fields and households. Cypermethrin is a type II pyrethroid which acts primarily by delaying the closure of voltage-sensitive sodium channels at higher concentrations. Its toxicity in humans occur due to accidental or intentional exposure through inhalation, skin contact or via ingestion. Acute oral intoxication of cypermethrin commonly manifests with neurotoxic and gastrointestinal effects in humans. Cardiotoxic effects following ingestion of this compound have occurred in a few cases but underreported to date. This case highlights a case of intentional cypermethrin poisoning with acute effects in the form of prolonged bradycardia symptomatically managed with a muscarinic antagonist like atropine sulphate. Elsevier 2020-12-10 /pmc/articles/PMC7750177/ /pubmed/33364178 http://dx.doi.org/10.1016/j.toxrep.2020.12.005 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Shilpakar, Olita Karki, Bipin Cypermethrin poisoning manifesting with prolonged bradycardia: A case report |
title | Cypermethrin poisoning manifesting with prolonged bradycardia: A case report |
title_full | Cypermethrin poisoning manifesting with prolonged bradycardia: A case report |
title_fullStr | Cypermethrin poisoning manifesting with prolonged bradycardia: A case report |
title_full_unstemmed | Cypermethrin poisoning manifesting with prolonged bradycardia: A case report |
title_short | Cypermethrin poisoning manifesting with prolonged bradycardia: A case report |
title_sort | cypermethrin poisoning manifesting with prolonged bradycardia: a case report |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750177/ https://www.ncbi.nlm.nih.gov/pubmed/33364178 http://dx.doi.org/10.1016/j.toxrep.2020.12.005 |
work_keys_str_mv | AT shilpakarolita cypermethrinpoisoningmanifestingwithprolongedbradycardiaacasereport AT karkibipin cypermethrinpoisoningmanifestingwithprolongedbradycardiaacasereport |