Physiological and Pathological Roles of Mammalian NEK7

NEK7 is the smallest NIMA-related kinase (NEK) in mammals. The pathological and physiological roles of NEK7 have been widely reported in many studies. To date, the major function of NEK7 has been well documented in mitosis and NLRP3 inflammasome activation, but the detailed mechanisms of its regulat...

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Autores principales: Sun, Zhenzhen, Gong, Wei, Zhang, Yue, Jia, Zhanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750478/
https://www.ncbi.nlm.nih.gov/pubmed/33364979
http://dx.doi.org/10.3389/fphys.2020.606996
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author Sun, Zhenzhen
Gong, Wei
Zhang, Yue
Jia, Zhanjun
author_facet Sun, Zhenzhen
Gong, Wei
Zhang, Yue
Jia, Zhanjun
author_sort Sun, Zhenzhen
collection PubMed
description NEK7 is the smallest NIMA-related kinase (NEK) in mammals. The pathological and physiological roles of NEK7 have been widely reported in many studies. To date, the major function of NEK7 has been well documented in mitosis and NLRP3 inflammasome activation, but the detailed mechanisms of its regulation remain unclear. This review summarizes current advances in NEK7 research involving mitotic regulation, NLRP3 inflammasome activation, related diseases and potential inhibitors, which may provide new insights into the understanding and therapy of the diseases associated with NEK7, as well as the subsequent studies in the future.
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spelling pubmed-77504782020-12-22 Physiological and Pathological Roles of Mammalian NEK7 Sun, Zhenzhen Gong, Wei Zhang, Yue Jia, Zhanjun Front Physiol Physiology NEK7 is the smallest NIMA-related kinase (NEK) in mammals. The pathological and physiological roles of NEK7 have been widely reported in many studies. To date, the major function of NEK7 has been well documented in mitosis and NLRP3 inflammasome activation, but the detailed mechanisms of its regulation remain unclear. This review summarizes current advances in NEK7 research involving mitotic regulation, NLRP3 inflammasome activation, related diseases and potential inhibitors, which may provide new insights into the understanding and therapy of the diseases associated with NEK7, as well as the subsequent studies in the future. Frontiers Media S.A. 2020-12-07 /pmc/articles/PMC7750478/ /pubmed/33364979 http://dx.doi.org/10.3389/fphys.2020.606996 Text en Copyright © 2020 Sun, Gong, Zhang and Jia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Sun, Zhenzhen
Gong, Wei
Zhang, Yue
Jia, Zhanjun
Physiological and Pathological Roles of Mammalian NEK7
title Physiological and Pathological Roles of Mammalian NEK7
title_full Physiological and Pathological Roles of Mammalian NEK7
title_fullStr Physiological and Pathological Roles of Mammalian NEK7
title_full_unstemmed Physiological and Pathological Roles of Mammalian NEK7
title_short Physiological and Pathological Roles of Mammalian NEK7
title_sort physiological and pathological roles of mammalian nek7
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750478/
https://www.ncbi.nlm.nih.gov/pubmed/33364979
http://dx.doi.org/10.3389/fphys.2020.606996
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