Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil)

PURPOSE: Examine the use of systemic phosphodiesterase inhibition (sildenafil) to clear central serous chorioretinopathy (CSCR). OBSERVATIONS: In a long-standing CSCR patient, sildenafil produced a rapid resolution. When discontinued (dechallenge) the CSCR returned. When rechallenged, the CSCR again...

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Detalles Bibliográficos
Autores principales: Coleman, D. Jackson, Lee, Winston, Daly, Suzanne, Breazzano, Mark P., Sparrow, Janet, Tsang, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750488/
https://www.ncbi.nlm.nih.gov/pubmed/33364520
http://dx.doi.org/10.1016/j.ajoc.2020.100998
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author Coleman, D. Jackson
Lee, Winston
Daly, Suzanne
Breazzano, Mark P.
Sparrow, Janet
Tsang, Stephen H.
author_facet Coleman, D. Jackson
Lee, Winston
Daly, Suzanne
Breazzano, Mark P.
Sparrow, Janet
Tsang, Stephen H.
author_sort Coleman, D. Jackson
collection PubMed
description PURPOSE: Examine the use of systemic phosphodiesterase inhibition (sildenafil) to clear central serous chorioretinopathy (CSCR). OBSERVATIONS: In a long-standing CSCR patient, sildenafil produced a rapid resolution. When discontinued (dechallenge) the CSCR returned. When rechallenged, the CSCR again rapidly disappeared and did not recur in 5 months of continued therapy. CONCLUSIONS: AND IMPORTANCE: Systemic sildenafil can cause rapid clearance of CSCR and can augment or replace other treatments.
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spelling pubmed-77504882020-12-23 Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil) Coleman, D. Jackson Lee, Winston Daly, Suzanne Breazzano, Mark P. Sparrow, Janet Tsang, Stephen H. Am J Ophthalmol Case Rep Case Report PURPOSE: Examine the use of systemic phosphodiesterase inhibition (sildenafil) to clear central serous chorioretinopathy (CSCR). OBSERVATIONS: In a long-standing CSCR patient, sildenafil produced a rapid resolution. When discontinued (dechallenge) the CSCR returned. When rechallenged, the CSCR again rapidly disappeared and did not recur in 5 months of continued therapy. CONCLUSIONS: AND IMPORTANCE: Systemic sildenafil can cause rapid clearance of CSCR and can augment or replace other treatments. Elsevier 2020-12-03 /pmc/articles/PMC7750488/ /pubmed/33364520 http://dx.doi.org/10.1016/j.ajoc.2020.100998 Text en © 2020 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Coleman, D. Jackson
Lee, Winston
Daly, Suzanne
Breazzano, Mark P.
Sparrow, Janet
Tsang, Stephen H.
Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil)
title Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil)
title_full Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil)
title_fullStr Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil)
title_full_unstemmed Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil)
title_short Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil)
title_sort central serous chorioretinopathy treatment with a systemic pde5 and pde6 inhibitor (sildenafil)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750488/
https://www.ncbi.nlm.nih.gov/pubmed/33364520
http://dx.doi.org/10.1016/j.ajoc.2020.100998
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