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Nanoparticles for Stem Cell Therapy Bioengineering in Glioma

Gliomas are a dismal disease associated with poor survival and high morbidity. Current standard treatments have reached a therapeutic plateau even after combining maximal safe resection, radiation, and chemotherapy. In this setting, stem cells (SCs) have risen as a promising therapeutic armamentariu...

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Autores principales: Ruiz-Garcia, Henry, Alvarado-Estrada, Keila, Krishnan, Sunil, Quinones-Hinojosa, Alfredo, Trifiletti, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750507/
https://www.ncbi.nlm.nih.gov/pubmed/33365304
http://dx.doi.org/10.3389/fbioe.2020.558375
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author Ruiz-Garcia, Henry
Alvarado-Estrada, Keila
Krishnan, Sunil
Quinones-Hinojosa, Alfredo
Trifiletti, Daniel M.
author_facet Ruiz-Garcia, Henry
Alvarado-Estrada, Keila
Krishnan, Sunil
Quinones-Hinojosa, Alfredo
Trifiletti, Daniel M.
author_sort Ruiz-Garcia, Henry
collection PubMed
description Gliomas are a dismal disease associated with poor survival and high morbidity. Current standard treatments have reached a therapeutic plateau even after combining maximal safe resection, radiation, and chemotherapy. In this setting, stem cells (SCs) have risen as a promising therapeutic armamentarium, given their intrinsic tumor homing as well as their natural or bioengineered antitumor properties. The interplay between stem cells and other therapeutic approaches such as nanoparticles holds the potential to synergize the advantages from the combined therapeutic strategies. Nanoparticles represent a broad spectrum of synthetic and natural biomaterials that have been proven effective in expanding diagnostic and therapeutic efforts, either used alone or in combination with immune, genetic, or cellular therapies. Stem cells have been bioengineered using these biomaterials to enhance their natural properties as well as to act as their vehicle when anticancer nanoparticles need to be delivered into the tumor microenvironment in a very precise manner. Here, we describe the recent developments of this new paradigm in the treatment of malignant gliomas.
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spelling pubmed-77505072020-12-22 Nanoparticles for Stem Cell Therapy Bioengineering in Glioma Ruiz-Garcia, Henry Alvarado-Estrada, Keila Krishnan, Sunil Quinones-Hinojosa, Alfredo Trifiletti, Daniel M. Front Bioeng Biotechnol Bioengineering and Biotechnology Gliomas are a dismal disease associated with poor survival and high morbidity. Current standard treatments have reached a therapeutic plateau even after combining maximal safe resection, radiation, and chemotherapy. In this setting, stem cells (SCs) have risen as a promising therapeutic armamentarium, given their intrinsic tumor homing as well as their natural or bioengineered antitumor properties. The interplay between stem cells and other therapeutic approaches such as nanoparticles holds the potential to synergize the advantages from the combined therapeutic strategies. Nanoparticles represent a broad spectrum of synthetic and natural biomaterials that have been proven effective in expanding diagnostic and therapeutic efforts, either used alone or in combination with immune, genetic, or cellular therapies. Stem cells have been bioengineered using these biomaterials to enhance their natural properties as well as to act as their vehicle when anticancer nanoparticles need to be delivered into the tumor microenvironment in a very precise manner. Here, we describe the recent developments of this new paradigm in the treatment of malignant gliomas. Frontiers Media S.A. 2020-12-07 /pmc/articles/PMC7750507/ /pubmed/33365304 http://dx.doi.org/10.3389/fbioe.2020.558375 Text en Copyright © 2020 Ruiz-Garcia, Alvarado-Estrada, Krishnan, Quinones-Hinojosa and Trifiletti. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Ruiz-Garcia, Henry
Alvarado-Estrada, Keila
Krishnan, Sunil
Quinones-Hinojosa, Alfredo
Trifiletti, Daniel M.
Nanoparticles for Stem Cell Therapy Bioengineering in Glioma
title Nanoparticles for Stem Cell Therapy Bioengineering in Glioma
title_full Nanoparticles for Stem Cell Therapy Bioengineering in Glioma
title_fullStr Nanoparticles for Stem Cell Therapy Bioengineering in Glioma
title_full_unstemmed Nanoparticles for Stem Cell Therapy Bioengineering in Glioma
title_short Nanoparticles for Stem Cell Therapy Bioengineering in Glioma
title_sort nanoparticles for stem cell therapy bioengineering in glioma
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750507/
https://www.ncbi.nlm.nih.gov/pubmed/33365304
http://dx.doi.org/10.3389/fbioe.2020.558375
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