Cargando…

Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy

Dystrophic neurites (DNs) are found in many neurological conditions such as traumatic brain injury and age-related neurodegenerative diseases. In Alzheimer’s disease (AD) specifically, senile plaques containing silver-stained DNs were already described in the original literature defining this diseas...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Yan-Bin, Tu, Tian, Jiang, Juan, Zhang, Qi-Lei, Ai, Jia-Qi, Pan, Aihua, Manavis, Jim, Tu, Ewen, Yan, Xiao-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750631/
https://www.ncbi.nlm.nih.gov/pubmed/33364934
http://dx.doi.org/10.3389/fnagi.2020.596894
_version_ 1783625517091520512
author Shi, Yan-Bin
Tu, Tian
Jiang, Juan
Zhang, Qi-Lei
Ai, Jia-Qi
Pan, Aihua
Manavis, Jim
Tu, Ewen
Yan, Xiao-Xin
author_facet Shi, Yan-Bin
Tu, Tian
Jiang, Juan
Zhang, Qi-Lei
Ai, Jia-Qi
Pan, Aihua
Manavis, Jim
Tu, Ewen
Yan, Xiao-Xin
author_sort Shi, Yan-Bin
collection PubMed
description Dystrophic neurites (DNs) are found in many neurological conditions such as traumatic brain injury and age-related neurodegenerative diseases. In Alzheimer’s disease (AD) specifically, senile plaques containing silver-stained DNs were already described in the original literature defining this disease. These DNs could be both axonal and dendritic in origin, while axonal dystrophy relative to plaque formation has been more extensively studied. Here, we demonstrate an early occurrence of dendritic dystrophy in the hippocampal CA1 and subicular regions in human brains (n = 23) with primary age-related tauopathy (PART), with neurofibrillary tangle (NFT) burden ranging from Braak stages I to III in the absence of cerebral β-amyloid (Aβ) deposition. In Bielschowsky’s silver stain, segmented fusiform swellings on the apical dendrites of hippocampal and subicular pyramidal neurons were observed in all the cases, primarily over the stratum radiatum (s.r.). The numbers of silver-stained neuronal somata and dendritic swellings counted over CA1 to subiculum were positively correlated among the cases. Swollen dendritic processes were also detected in sections immunolabeled for phosphorylated tau (pTau) and sortilin. In aged and AD brains with both Aβ and pTau pathologies, silver- and immunolabeled dystrophic-like dendritic profiles occurred around and within individual neuritic plaques. These findings implicate that dendritic dystrophy can occur among hippocampal pyramidal neurons in human brains with PART. Therefore, as with the case of axonal dystrophy reported in literature, dendritic dystrophy can develop prior to Alzheimer-type plaque and tangle formation in the human brain.
format Online
Article
Text
id pubmed-7750631
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-77506312020-12-22 Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy Shi, Yan-Bin Tu, Tian Jiang, Juan Zhang, Qi-Lei Ai, Jia-Qi Pan, Aihua Manavis, Jim Tu, Ewen Yan, Xiao-Xin Front Aging Neurosci Neuroscience Dystrophic neurites (DNs) are found in many neurological conditions such as traumatic brain injury and age-related neurodegenerative diseases. In Alzheimer’s disease (AD) specifically, senile plaques containing silver-stained DNs were already described in the original literature defining this disease. These DNs could be both axonal and dendritic in origin, while axonal dystrophy relative to plaque formation has been more extensively studied. Here, we demonstrate an early occurrence of dendritic dystrophy in the hippocampal CA1 and subicular regions in human brains (n = 23) with primary age-related tauopathy (PART), with neurofibrillary tangle (NFT) burden ranging from Braak stages I to III in the absence of cerebral β-amyloid (Aβ) deposition. In Bielschowsky’s silver stain, segmented fusiform swellings on the apical dendrites of hippocampal and subicular pyramidal neurons were observed in all the cases, primarily over the stratum radiatum (s.r.). The numbers of silver-stained neuronal somata and dendritic swellings counted over CA1 to subiculum were positively correlated among the cases. Swollen dendritic processes were also detected in sections immunolabeled for phosphorylated tau (pTau) and sortilin. In aged and AD brains with both Aβ and pTau pathologies, silver- and immunolabeled dystrophic-like dendritic profiles occurred around and within individual neuritic plaques. These findings implicate that dendritic dystrophy can occur among hippocampal pyramidal neurons in human brains with PART. Therefore, as with the case of axonal dystrophy reported in literature, dendritic dystrophy can develop prior to Alzheimer-type plaque and tangle formation in the human brain. Frontiers Media S.A. 2020-12-07 /pmc/articles/PMC7750631/ /pubmed/33364934 http://dx.doi.org/10.3389/fnagi.2020.596894 Text en Copyright © 2020 Shi, Tu, Jiang, Zhang, Ai, Pan, Manavis, Tu and Yan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Shi, Yan-Bin
Tu, Tian
Jiang, Juan
Zhang, Qi-Lei
Ai, Jia-Qi
Pan, Aihua
Manavis, Jim
Tu, Ewen
Yan, Xiao-Xin
Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy
title Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy
title_full Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy
title_fullStr Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy
title_full_unstemmed Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy
title_short Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy
title_sort early dendritic dystrophy in human brains with primary age-related tauopathy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750631/
https://www.ncbi.nlm.nih.gov/pubmed/33364934
http://dx.doi.org/10.3389/fnagi.2020.596894
work_keys_str_mv AT shiyanbin earlydendriticdystrophyinhumanbrainswithprimaryagerelatedtauopathy
AT tutian earlydendriticdystrophyinhumanbrainswithprimaryagerelatedtauopathy
AT jiangjuan earlydendriticdystrophyinhumanbrainswithprimaryagerelatedtauopathy
AT zhangqilei earlydendriticdystrophyinhumanbrainswithprimaryagerelatedtauopathy
AT aijiaqi earlydendriticdystrophyinhumanbrainswithprimaryagerelatedtauopathy
AT panaihua earlydendriticdystrophyinhumanbrainswithprimaryagerelatedtauopathy
AT manavisjim earlydendriticdystrophyinhumanbrainswithprimaryagerelatedtauopathy
AT tuewen earlydendriticdystrophyinhumanbrainswithprimaryagerelatedtauopathy
AT yanxiaoxin earlydendriticdystrophyinhumanbrainswithprimaryagerelatedtauopathy