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Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy
Dystrophic neurites (DNs) are found in many neurological conditions such as traumatic brain injury and age-related neurodegenerative diseases. In Alzheimer’s disease (AD) specifically, senile plaques containing silver-stained DNs were already described in the original literature defining this diseas...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750631/ https://www.ncbi.nlm.nih.gov/pubmed/33364934 http://dx.doi.org/10.3389/fnagi.2020.596894 |
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author | Shi, Yan-Bin Tu, Tian Jiang, Juan Zhang, Qi-Lei Ai, Jia-Qi Pan, Aihua Manavis, Jim Tu, Ewen Yan, Xiao-Xin |
author_facet | Shi, Yan-Bin Tu, Tian Jiang, Juan Zhang, Qi-Lei Ai, Jia-Qi Pan, Aihua Manavis, Jim Tu, Ewen Yan, Xiao-Xin |
author_sort | Shi, Yan-Bin |
collection | PubMed |
description | Dystrophic neurites (DNs) are found in many neurological conditions such as traumatic brain injury and age-related neurodegenerative diseases. In Alzheimer’s disease (AD) specifically, senile plaques containing silver-stained DNs were already described in the original literature defining this disease. These DNs could be both axonal and dendritic in origin, while axonal dystrophy relative to plaque formation has been more extensively studied. Here, we demonstrate an early occurrence of dendritic dystrophy in the hippocampal CA1 and subicular regions in human brains (n = 23) with primary age-related tauopathy (PART), with neurofibrillary tangle (NFT) burden ranging from Braak stages I to III in the absence of cerebral β-amyloid (Aβ) deposition. In Bielschowsky’s silver stain, segmented fusiform swellings on the apical dendrites of hippocampal and subicular pyramidal neurons were observed in all the cases, primarily over the stratum radiatum (s.r.). The numbers of silver-stained neuronal somata and dendritic swellings counted over CA1 to subiculum were positively correlated among the cases. Swollen dendritic processes were also detected in sections immunolabeled for phosphorylated tau (pTau) and sortilin. In aged and AD brains with both Aβ and pTau pathologies, silver- and immunolabeled dystrophic-like dendritic profiles occurred around and within individual neuritic plaques. These findings implicate that dendritic dystrophy can occur among hippocampal pyramidal neurons in human brains with PART. Therefore, as with the case of axonal dystrophy reported in literature, dendritic dystrophy can develop prior to Alzheimer-type plaque and tangle formation in the human brain. |
format | Online Article Text |
id | pubmed-7750631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77506312020-12-22 Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy Shi, Yan-Bin Tu, Tian Jiang, Juan Zhang, Qi-Lei Ai, Jia-Qi Pan, Aihua Manavis, Jim Tu, Ewen Yan, Xiao-Xin Front Aging Neurosci Neuroscience Dystrophic neurites (DNs) are found in many neurological conditions such as traumatic brain injury and age-related neurodegenerative diseases. In Alzheimer’s disease (AD) specifically, senile plaques containing silver-stained DNs were already described in the original literature defining this disease. These DNs could be both axonal and dendritic in origin, while axonal dystrophy relative to plaque formation has been more extensively studied. Here, we demonstrate an early occurrence of dendritic dystrophy in the hippocampal CA1 and subicular regions in human brains (n = 23) with primary age-related tauopathy (PART), with neurofibrillary tangle (NFT) burden ranging from Braak stages I to III in the absence of cerebral β-amyloid (Aβ) deposition. In Bielschowsky’s silver stain, segmented fusiform swellings on the apical dendrites of hippocampal and subicular pyramidal neurons were observed in all the cases, primarily over the stratum radiatum (s.r.). The numbers of silver-stained neuronal somata and dendritic swellings counted over CA1 to subiculum were positively correlated among the cases. Swollen dendritic processes were also detected in sections immunolabeled for phosphorylated tau (pTau) and sortilin. In aged and AD brains with both Aβ and pTau pathologies, silver- and immunolabeled dystrophic-like dendritic profiles occurred around and within individual neuritic plaques. These findings implicate that dendritic dystrophy can occur among hippocampal pyramidal neurons in human brains with PART. Therefore, as with the case of axonal dystrophy reported in literature, dendritic dystrophy can develop prior to Alzheimer-type plaque and tangle formation in the human brain. Frontiers Media S.A. 2020-12-07 /pmc/articles/PMC7750631/ /pubmed/33364934 http://dx.doi.org/10.3389/fnagi.2020.596894 Text en Copyright © 2020 Shi, Tu, Jiang, Zhang, Ai, Pan, Manavis, Tu and Yan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Shi, Yan-Bin Tu, Tian Jiang, Juan Zhang, Qi-Lei Ai, Jia-Qi Pan, Aihua Manavis, Jim Tu, Ewen Yan, Xiao-Xin Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy |
title | Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy |
title_full | Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy |
title_fullStr | Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy |
title_full_unstemmed | Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy |
title_short | Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy |
title_sort | early dendritic dystrophy in human brains with primary age-related tauopathy |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750631/ https://www.ncbi.nlm.nih.gov/pubmed/33364934 http://dx.doi.org/10.3389/fnagi.2020.596894 |
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