Cargando…

Multifocal cutaneous non-epitheliotropic B-cell lymphoma in a cat

CASE SUMMARY: Skin tumours are the second-most common form of feline cancer after haematopoietic neoplasms and are often malignant. Cutaneous lymphoma is uncommon in cats and can be classified as epitheliotropic (typically of T-cell origin) or non-epitheliotropic (either of T-cell or B-cell origin)....

Descripción completa

Detalles Bibliográficos
Autores principales: Quintavalla, Fausto, Di Lecce, Rosanna, Carlini, Daniele, Zanfabro, Matteo, Cantoni, Anna M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750760/
https://www.ncbi.nlm.nih.gov/pubmed/33414925
http://dx.doi.org/10.1177/2055116920972077
_version_ 1783625542896975872
author Quintavalla, Fausto
Di Lecce, Rosanna
Carlini, Daniele
Zanfabro, Matteo
Cantoni, Anna M
author_facet Quintavalla, Fausto
Di Lecce, Rosanna
Carlini, Daniele
Zanfabro, Matteo
Cantoni, Anna M
author_sort Quintavalla, Fausto
collection PubMed
description CASE SUMMARY: Skin tumours are the second-most common form of feline cancer after haematopoietic neoplasms and are often malignant. Cutaneous lymphoma is uncommon in cats and can be classified as epitheliotropic (typically of T-cell origin) or non-epitheliotropic (either of T-cell or B-cell origin). The present study describes a case of multifocal cutaneous non-epitheliotropic B-cell lymphoma. The skin nodules were multiple and variable in size; showed rapid progression; were alopecic and erythematous in appearance and pruritic and ulcerated; and were mostly located on the trunk. Nodule biopsies revealed the presence of uniform medium-to-large round neoplastic cells that infiltrated the dermis and subcutis. The neoplasias were consistent with a round cell cutaneous tumour and did not show evidence of epitheliotropism. Furthermore, immunohistochemical assessments indicated an immunophenotype characterised by round cells with a strong membrane and cytoplasmic positivity for the CD20 antigen, consistent with a lymphocyte of B-cell origin. RELEVANCE AND NOVEL INFORMATION: Cutaneous non-epitheliotropic B-cell lymphoma in cats is rare and was previously reported to appear as single dermal and subcutaneous masses that are variable in size and generally develop in the tarsal region. To our knowledge, this is the first report to describe multifocal cutaneous non-epitheliotropic B-cell lymphoma in a cat.
format Online
Article
Text
id pubmed-7750760
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-77507602021-01-06 Multifocal cutaneous non-epitheliotropic B-cell lymphoma in a cat Quintavalla, Fausto Di Lecce, Rosanna Carlini, Daniele Zanfabro, Matteo Cantoni, Anna M JFMS Open Rep Case Report CASE SUMMARY: Skin tumours are the second-most common form of feline cancer after haematopoietic neoplasms and are often malignant. Cutaneous lymphoma is uncommon in cats and can be classified as epitheliotropic (typically of T-cell origin) or non-epitheliotropic (either of T-cell or B-cell origin). The present study describes a case of multifocal cutaneous non-epitheliotropic B-cell lymphoma. The skin nodules were multiple and variable in size; showed rapid progression; were alopecic and erythematous in appearance and pruritic and ulcerated; and were mostly located on the trunk. Nodule biopsies revealed the presence of uniform medium-to-large round neoplastic cells that infiltrated the dermis and subcutis. The neoplasias were consistent with a round cell cutaneous tumour and did not show evidence of epitheliotropism. Furthermore, immunohistochemical assessments indicated an immunophenotype characterised by round cells with a strong membrane and cytoplasmic positivity for the CD20 antigen, consistent with a lymphocyte of B-cell origin. RELEVANCE AND NOVEL INFORMATION: Cutaneous non-epitheliotropic B-cell lymphoma in cats is rare and was previously reported to appear as single dermal and subcutaneous masses that are variable in size and generally develop in the tarsal region. To our knowledge, this is the first report to describe multifocal cutaneous non-epitheliotropic B-cell lymphoma in a cat. SAGE Publications 2020-12-16 /pmc/articles/PMC7750760/ /pubmed/33414925 http://dx.doi.org/10.1177/2055116920972077 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Quintavalla, Fausto
Di Lecce, Rosanna
Carlini, Daniele
Zanfabro, Matteo
Cantoni, Anna M
Multifocal cutaneous non-epitheliotropic B-cell lymphoma in a cat
title Multifocal cutaneous non-epitheliotropic B-cell lymphoma in a cat
title_full Multifocal cutaneous non-epitheliotropic B-cell lymphoma in a cat
title_fullStr Multifocal cutaneous non-epitheliotropic B-cell lymphoma in a cat
title_full_unstemmed Multifocal cutaneous non-epitheliotropic B-cell lymphoma in a cat
title_short Multifocal cutaneous non-epitheliotropic B-cell lymphoma in a cat
title_sort multifocal cutaneous non-epitheliotropic b-cell lymphoma in a cat
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750760/
https://www.ncbi.nlm.nih.gov/pubmed/33414925
http://dx.doi.org/10.1177/2055116920972077
work_keys_str_mv AT quintavallafausto multifocalcutaneousnonepitheliotropicbcelllymphomainacat
AT dileccerosanna multifocalcutaneousnonepitheliotropicbcelllymphomainacat
AT carlinidaniele multifocalcutaneousnonepitheliotropicbcelllymphomainacat
AT zanfabromatteo multifocalcutaneousnonepitheliotropicbcelllymphomainacat
AT cantoniannam multifocalcutaneousnonepitheliotropicbcelllymphomainacat