Cargando…

Phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories revealed by AI-MiXeR

MOTIVATION: Determining the relative contributions of functional genetic categories is fundamental to understanding the genetic etiology of complex human traits and diseases. Here, we present Annotation Informed-MiXeR, a likelihood-based method for estimating the number of variants influencing a phe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shadrin, Alexey A, Frei, Oleksandr, Smeland, Olav B, Bettella, Francesco, O'Connell, Kevin S, Gani, Osman, Bahrami, Shahram, Uggen, Tea K E, Djurovic, Srdjan, Holland, Dominic, Andreassen, Ole A, Dale, Anders M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750998/ https://www.ncbi.nlm.nih.gov/pubmed/32539089 http://dx.doi.org/10.1093/bioinformatics/btaa568

Ejemplares similares

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
por: Frei, Oleksandr, et al.
Publicado: (2019)

Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking
por: Hindley, Guy, et al.
Publicado: (2021)

Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors
por: Torgersen, Kristin, et al.
Publicado: (2021)

Genetic loci shared between major depression and intelligence with mixed directions of effect
por: Bahrami, Shahram, et al.
Publicado: (2021)

Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms
por: Rødevand, Linn, et al.
Publicado: (2021)

Shared genetic loci between depression and cardiometabolic traits
por: Torgersen, Kristin, et al.
Publicado: (2022)

Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools
por: Bahrami, Shahram, et al.
Publicado: (2021)

Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model
por: Holland, Dominic, et al.
Publicado: (2020)

Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes
por: Rødevand, Linn, et al.
Publicado: (2021)

Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls
por: Engen, Magnus Johan, et al.
Publicado: (2020)

Identification of Novel Genomic Loci for Anxiety and Extensive Genetic Overlap with Psychiatric Disorders
por: Tesfaye, Markos, et al.
Publicado: (2023)

The shared genetic basis of mood instability and psychiatric disorders: A cross‐trait genome‐wide association analysis
por: Hindley, Guy, et al.
Publicado: (2022)

Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis
por: Tesfaye, Markos, et al.
Publicado: (2023)

Phenotype‐informed polygenic risk scores are associated with worse outcome in individuals at risk of Alzheimer's disease
por: Nordengen, Kaja, et al.
Publicado: (2022)

Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes
por: Drange, Ole Kristian, et al.
Publicado: (2019)

The genetic architecture of the human thalamus and its overlap with ten common brain disorders
por: Elvsåshagen, Torbjørn, et al.
Publicado: (2021)

Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders
por: Karadag, Naz, et al.
Publicado: (2023)

Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci
por: Jaholkowski, Piotr, et al.
Publicado: (2023)

Genome-wide analysis of anorexia nervosa and major psychiatric disorders and related traits reveals genetic overlap and identifies novel risk loci for anorexia nervosa
por: Bang, Lasse, et al.
Publicado: (2023)

Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities
por: Steen, Nils Eiel, et al.
Publicado: (2023)

The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis
por: Smeland, Olav B., et al.
Publicado: (2023)

Altered Brain Activation during Emotional Face Processing in Relation to Both Diagnosis and Polygenic Risk of Bipolar Disorder
por: Tesli, Martin, et al.
Publicado: (2015)

Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank
por: O'Connell, Kevin S., et al.
Publicado: (2022)

Bidirectional genetic overlap between autism spectrum disorder and cognitive traits
por: Hope, Sigrun, et al.
Publicado: (2023)

Enrichment of genetic markers of recent human evolution in educational and cognitive traits
por: Srinivasan, Saurabh, et al.
Publicado: (2018)

Cross-tissue eQTL enrichment of associations in schizophrenia
por: Bettella, Francesco, et al.
Publicado: (2018)

Association between Genetic Variation in the Oxytocin Receptor Gene and Emotional Withdrawal, but not between Oxytocin Pathway Genes and Diagnosis in Psychotic Disorders
por: Haram, Marit, et al.
Publicado: (2015)

Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders
por: Doan, Nhat Trung, et al.
Publicado: (2017)

Identification of shared genetic variants between schizophrenia and lung cancer
por: Zuber, Verena, et al.
Publicado: (2018)

Genetic Overlap Between Alzheimer’s Disease and Depression Mapped Onto the Brain
por: Monereo-Sánchez, Jennifer, et al.
Publicado: (2021)

A Breast Cancer Polygenic Risk Score Is Feasible for Risk Stratification in the Norwegian Population
por: Akdeniz, Bayram Cevdet, et al.
Publicado: (2023)

Identification of genetic loci shared between schizophrenia and the Big Five personality traits
por: Smeland, Olav B., et al.
Publicado: (2017)

Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders
por: Osete, Jordi Requena, et al.
Publicado: (2021)

Author Correction: Understanding the genetic determinants of the brain with MOSTest
por: van der Meer, Dennis, et al.
Publicado: (2020)

Understanding the genetic determinants of the brain with MOSTest
por: van der Meer, Dennis, et al.
Publicado: (2020)

Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis
por: Werner, Maren Caroline Frogner, et al.
Publicado: (2022)

Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders
por: Bahrami, Shahram, et al.
Publicado: (2022)

Microwave mixers
por: Maas, Stephen A
Publicado: (1993)

Microwave mixers
por: Pound, Robert V
Publicado: (1948)

Large-scale genomics unveil polygenic architecture of human cortical surface area
por: Chen, Chi-Hua, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_2iuasjlkdfgf1fkg0mbifj9pel