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MegaPath: sensitive and rapid pathogen detection using metagenomic NGS data
BACKGROUND: Next-generation sequencing (NGS) enables unbiased detection of pathogens by mapping the sequencing reads of a patient sample to the known reference sequence of bacteria and viruses. However, for a new pathogen without a reference sequence of a close relative, or with a high load of mutat...
Autores principales: | Leung, Chi-Ming, Li, Dinghua, Xin, Yan, Law, Wai-Chun, Zhang, Yifan, Ting, Hing-Fung, Luo, Ruibang, Lam, Tak-Wah |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751095/ https://www.ncbi.nlm.nih.gov/pubmed/33349238 http://dx.doi.org/10.1186/s12864-020-06875-6 |
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