Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro

SARS-CoV-2 uses human angiotensin-converting enzyme 2 (ACE2) as the primary receptor to enter host cells and initiate the infection. The critical binding region of ACE2 is an ∼30-amino-acid (aa)-long helix. Here, we report the design of four stapled peptides based on the ACE2 helix, which is expecte...

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Detalles Bibliográficos
Autores principales: Curreli, Francesca, Victor, Sofia M. B., Ahmed, Shahad, Drelich, Aleksandra, Tong, Xiaohe, Tseng, Chien-Te K., Hillyer, Christopher D., Debnath, Asim K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751257/
https://www.ncbi.nlm.nih.gov/pubmed/33310780
http://dx.doi.org/10.1128/mBio.02451-20

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