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Experimental Carbonic Anhydrase Inhibitors for the Treatment of Hypoxic Tumors
Carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII are overexpressed in many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation cascade, being present in limited amounts in normal tissues. These enzymes together with many others are involved in the pH regulation an...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751321/ https://www.ncbi.nlm.nih.gov/pubmed/33364855 http://dx.doi.org/10.2147/JEP.S265620 |