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Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies

The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids were designed and synthesised as dual CDK2/GSK-3β inhibitors targeting breast cancer (5a–g, 7a–h, and 13a–b). The N(1)-uns...

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Detalles Bibliográficos
Autores principales:	Eldehna, Wagdy M., Al-Rashood, Sara T., Al-Warhi, Tarfah, Eskandrani, Razan O., Alharbi, Amal, El Kerdawy, Ahmed M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751407/ https://www.ncbi.nlm.nih.gov/pubmed/33327806 http://dx.doi.org/10.1080/14756366.2020.1862101

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