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Unnecessary antimicrobial prescribing for upper respiratory tract infections in children in Pietermaritzburg, South Africa

BACKGROUND: Acute upper respiratory tract infections (URTIs) are contagious diseases of the upper airways, but they are self-limiting in nature. Therefore, antimicrobial-use for the majority of the URTIs is considered inappropriate. Unfortunately, globally, antimicrobials are still being prescribed...

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Autores principales: Mathibe, Lehlohonolo John, Zwane, Nonhle Perseverance
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751518/
https://www.ncbi.nlm.nih.gov/pubmed/33402958
http://dx.doi.org/10.4314/ahs.v20i3.15
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author Mathibe, Lehlohonolo John
Zwane, Nonhle Perseverance
author_facet Mathibe, Lehlohonolo John
Zwane, Nonhle Perseverance
author_sort Mathibe, Lehlohonolo John
collection PubMed
description BACKGROUND: Acute upper respiratory tract infections (URTIs) are contagious diseases of the upper airways, but they are self-limiting in nature. Therefore, antimicrobial-use for the majority of the URTIs is considered inappropriate. Unfortunately, globally, antimicrobials are still being prescribed for the treatment of URTIs, especially in children. However, there is insufficient evidence on the causes of this phenomenon in South Africa. OBJECTIVE: To investigate whether the parents/guardians accompanying children with URTIs expected/influenced physicians and/or nurses to prescribe antibiotics. METHODS: This was a prospective descriptive and explorative questionnaire-based study. Participants were guardians who accompanied children aged five years and below, diagnosed with acute URTIs. FINDINGS: Three hundred and six parents/guardians participated in this study. Seventy six percent (n=233) of participants received antibiotics for URTIs for their children, and 67% (n=156) of these did not make requests for antimicrobial therapy. On overall, there was a statistically significant (p < 0.0001) chance (with OR of 5.9; 95% CI, 2.4 – 14.2) for receiving antibiotics for URTIs without a request. CONCLUSION: Physicians and other healthcare providers need education on rational prescribing of antimicrobials, and to implement evidence-based standard treatment guidelines, to reduce inappropriate use of antibiotics in children with self-limiting URTIs.
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spelling pubmed-77515182021-01-04 Unnecessary antimicrobial prescribing for upper respiratory tract infections in children in Pietermaritzburg, South Africa Mathibe, Lehlohonolo John Zwane, Nonhle Perseverance Afr Health Sci Articles BACKGROUND: Acute upper respiratory tract infections (URTIs) are contagious diseases of the upper airways, but they are self-limiting in nature. Therefore, antimicrobial-use for the majority of the URTIs is considered inappropriate. Unfortunately, globally, antimicrobials are still being prescribed for the treatment of URTIs, especially in children. However, there is insufficient evidence on the causes of this phenomenon in South Africa. OBJECTIVE: To investigate whether the parents/guardians accompanying children with URTIs expected/influenced physicians and/or nurses to prescribe antibiotics. METHODS: This was a prospective descriptive and explorative questionnaire-based study. Participants were guardians who accompanied children aged five years and below, diagnosed with acute URTIs. FINDINGS: Three hundred and six parents/guardians participated in this study. Seventy six percent (n=233) of participants received antibiotics for URTIs for their children, and 67% (n=156) of these did not make requests for antimicrobial therapy. On overall, there was a statistically significant (p < 0.0001) chance (with OR of 5.9; 95% CI, 2.4 – 14.2) for receiving antibiotics for URTIs without a request. CONCLUSION: Physicians and other healthcare providers need education on rational prescribing of antimicrobials, and to implement evidence-based standard treatment guidelines, to reduce inappropriate use of antibiotics in children with self-limiting URTIs. Makerere Medical School 2020-09 /pmc/articles/PMC7751518/ /pubmed/33402958 http://dx.doi.org/10.4314/ahs.v20i3.15 Text en © 2020 Mathibe LJ et al. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Mathibe, Lehlohonolo John
Zwane, Nonhle Perseverance
Unnecessary antimicrobial prescribing for upper respiratory tract infections in children in Pietermaritzburg, South Africa
title Unnecessary antimicrobial prescribing for upper respiratory tract infections in children in Pietermaritzburg, South Africa
title_full Unnecessary antimicrobial prescribing for upper respiratory tract infections in children in Pietermaritzburg, South Africa
title_fullStr Unnecessary antimicrobial prescribing for upper respiratory tract infections in children in Pietermaritzburg, South Africa
title_full_unstemmed Unnecessary antimicrobial prescribing for upper respiratory tract infections in children in Pietermaritzburg, South Africa
title_short Unnecessary antimicrobial prescribing for upper respiratory tract infections in children in Pietermaritzburg, South Africa
title_sort unnecessary antimicrobial prescribing for upper respiratory tract infections in children in pietermaritzburg, south africa
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751518/
https://www.ncbi.nlm.nih.gov/pubmed/33402958
http://dx.doi.org/10.4314/ahs.v20i3.15
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