Cargando…

The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers

N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene(FTO), previously recognized to be related with obesity and diabetes, was gradually discovered to be dysregulated in multiple cancers and plays an oncogenic or tumor-suppressive role. However, the specific expression and pro- o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jin-yan, Chen, Li-juan, Qiang, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751723/ https://www.ncbi.nlm.nih.gov/pubmed/33364780 http://dx.doi.org/10.2147/OTT.S283417

Ejemplares similares

Roles of N6‐Methyladenosine Demethylase FTO in Malignant Tumors Progression
por: Zheng, Qing-Kang, et al.
Publicado: (2021)

Nitric oxide inhibits FTO demethylase activity to regulate N(6)-methyladenosine mRNA methylation
por: Kuschman, Hannah Petraitis, et al.
Publicado: (2023)

N(6)-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury
por: Xu, Kaiwei, et al.
Publicado: (2020)

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing
por: Bartosovic, Marek, et al.
Publicado: (2017)

N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability
por: Zou, Libin, et al.
Publicado: (2022)

Fat mass and obesity-associated factor (FTO)-mediated N6-methyladenosine regulates spermatogenesis in an age-dependent manner
por: Wu, Yifei, et al.
Publicado: (2023)

RNA N6-methyladenosine demethylase FTO promotes osteoporosis through demethylating Runx2 mRNA and inhibiting osteogenic differentiation
por: Wang, Jing, et al.
Publicado: (2021)

N(6)-Methyladenosine RNA Demethylase FTO Promotes Gastric Cancer Metastasis by Down-Regulating the m6A Methylation of ITGB1
por: Wang, Duo, et al.
Publicado: (2021)

A novel inhibitor of N(6)-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities
por: Xie, Guoyou, et al.
Publicado: (2022)

N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
por: Zou, Shui, et al.
Publicado: (2016)

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
por: Niu, Yi, et al.
Publicado: (2019)

m6A demethylase FTO and osteoporosis: potential therapeutic interventions
por: Huang, Mei, et al.
Publicado: (2023)

A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N(6)-methyladenosine demethylase activity in cells
por: Cheong, Adeline, et al.
Publicado: (2018)

N(6)‐Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons
por: Li, Yize, et al.
Publicado: (2020)

N6‐methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO‐PGC‐1α signalling axis
por: Zhuang, Changshui, et al.
Publicado: (2019)

N6-methyladenosine demethylase FTO promotes growth and metastasis of gastric cancer via m(6)A modification of caveolin-1 and metabolic regulation of mitochondrial dynamics
por: Zhou, You, et al.
Publicado: (2022)

RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m(6)A-YTHDF2-dependent manner
por: Tan, Zhen, et al.
Publicado: (2022)

FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms
por: Azzam, Sarah Kassem, et al.
Publicado: (2022)

N(6)-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO
por: Jia, Guifang, et al.
Publicado: (2011)

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
por: Zhao, Xu, et al.
Publicado: (2014)

The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation
por: Zhang, Meizi, et al.
Publicado: (2015)

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N (6)-methyladenosine demethylase FTO
por: Toh, Joel D. W., et al.
Publicado: (2015)

The RNA N6-Methyladenosine Demethylase FTO Promotes Head and Neck Squamous Cell Carcinoma Proliferation and Migration by Increasing CTNNB1
por: Zhang, Yu, et al.
Publicado: (2021)

N6-methyladenosine demethylase FTO impairs hepatic ischemia–reperfusion injury via inhibiting Drp1-mediated mitochondrial fragmentation
por: Du, Ying Dong, et al.
Publicado: (2021)

N(6) ‐methyladenosine RNA demethylase FTO regulates extracellular matrix‐related genes and promotes pancreatic cancer cell migration and invasion
por: Wang, Wei, et al.
Publicado: (2022)

Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression
por: Shan, Hong-Jian, et al.
Publicado: (2022)

The controversial role and therapeutic development of the m6A demethylase FTO in renal cell carcinoma
por: Zhang, Dalin, et al.
Publicado: (2022)

Substrates of the m(6)A demethylase FTO: FTO-LINE1 RNA axis regulates chromatin state in mESCs
por: Sommerkamp, Pia
Publicado: (2022)

Potential roles of N6-methyladenosine (m6A) in immune cells
por: Liu, Chang, et al.
Publicado: (2021)

Pan-Cancer Analysis of the N6-Methyladenosine Eraser FTO as a Potential Prognostic and Immunological Biomarker
por: Zhao, Chengwen, et al.
Publicado: (2021)

The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome.
por: Tsukuda, Senko, et al.
Publicado: (2023)

The role of m(6)A demethylase FTO in chemotherapy resistance mediating acute myeloid leukemia relapse
por: Zhang, Zhi-Wei, et al.
Publicado: (2023)

The Functional Role and Regulatory Mechanism of FTO m(6)A RNA Demethylase in Human Uterine Leiomyosarcoma
por: Yang, Qiwei, et al.
Publicado: (2023)

Regulatory role of N(6)-methyladenosine in intramuscular fat deposition in chicken
por: Zhang, Tong, et al.
Publicado: (2023)

Emerging Roles of N6-Methyladenosine Demethylases and Its Interaction with Environmental Toxicants in Digestive System Cancers
por: Liu, Caiping, et al.
Publicado: (2021)

AlkB RNA demethylase homologues and N (6) ‐methyladenosine are involved in Potyvirus infection
por: Yue, Jianying, et al.
Publicado: (2022)

Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5
por: Wang, Dong, et al.
Publicado: (2023)

Rational Design and Optimization of m(6)A-RNA Demethylase FTO Inhibitors as Anticancer Agents
por: Huff, Sarah, et al.
Publicado: (2022)

m(6)A demethylase FTO regulate CTNNB1 to promote adipogenesis of chicken preadipocyte
por: Li, Kan, et al.
Publicado: (2022)

The role of N6-methyladenosine (m(6)A) in kidney diseases
por: You, Luling, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_12nrqnisffbs9o6sdpclghfl5q