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Roles of Hydrogen Sulfide Donors in Common Kidney Diseases
Hydrogen sulfide (H(2)S) plays a key role in the regulation of physiological processes in mammals. The decline in H(2)S level has been reported in numerous renal disorders. In animal models of renal disorders, treatment with H(2)S donors could restore H(2)S levels and improve renal functions. H(2)S...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751760/ https://www.ncbi.nlm.nih.gov/pubmed/33364941 http://dx.doi.org/10.3389/fphar.2020.564281 |
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author | Ngowi, Ebenezeri Erasto Sarfraz, Muhammad Afzal, Attia Khan, Nazeer Hussain Khattak, Saadullah Zhang, Xin Li, Tao Duan, Shao-Feng Ji, Xin-Ying Wu, Dong-Dong |
author_facet | Ngowi, Ebenezeri Erasto Sarfraz, Muhammad Afzal, Attia Khan, Nazeer Hussain Khattak, Saadullah Zhang, Xin Li, Tao Duan, Shao-Feng Ji, Xin-Ying Wu, Dong-Dong |
author_sort | Ngowi, Ebenezeri Erasto |
collection | PubMed |
description | Hydrogen sulfide (H(2)S) plays a key role in the regulation of physiological processes in mammals. The decline in H(2)S level has been reported in numerous renal disorders. In animal models of renal disorders, treatment with H(2)S donors could restore H(2)S levels and improve renal functions. H(2)S donors suppress renal dysfunction by regulating autophagy, apoptosis, oxidative stress, and inflammation through multiple signaling pathways, such as TRL4/NLRP3, AMP-activated protein kinase/mammalian target of rapamycin, transforming growth factor-β1/Smad3, extracellular signal-regulated protein kinases 1/2, mitogen-activated protein kinase, and nuclear factor kappa B. In this review, we summarize recent developments in the effects of H(2)S donors on the treatment of common renal diseases, including acute/chronic kidney disease, renal fibrosis, unilateral ureteral obstruction, glomerulosclerosis, diabetic nephropathy, hyperhomocysteinemia, drug-induced nephrotoxicity, metal-induced nephrotoxicity, and urolithiasis. Novel H(2)S donors can be designed and applied in the treatment of common renal diseases. |
format | Online Article Text |
id | pubmed-7751760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77517602020-12-22 Roles of Hydrogen Sulfide Donors in Common Kidney Diseases Ngowi, Ebenezeri Erasto Sarfraz, Muhammad Afzal, Attia Khan, Nazeer Hussain Khattak, Saadullah Zhang, Xin Li, Tao Duan, Shao-Feng Ji, Xin-Ying Wu, Dong-Dong Front Pharmacol Pharmacology Hydrogen sulfide (H(2)S) plays a key role in the regulation of physiological processes in mammals. The decline in H(2)S level has been reported in numerous renal disorders. In animal models of renal disorders, treatment with H(2)S donors could restore H(2)S levels and improve renal functions. H(2)S donors suppress renal dysfunction by regulating autophagy, apoptosis, oxidative stress, and inflammation through multiple signaling pathways, such as TRL4/NLRP3, AMP-activated protein kinase/mammalian target of rapamycin, transforming growth factor-β1/Smad3, extracellular signal-regulated protein kinases 1/2, mitogen-activated protein kinase, and nuclear factor kappa B. In this review, we summarize recent developments in the effects of H(2)S donors on the treatment of common renal diseases, including acute/chronic kidney disease, renal fibrosis, unilateral ureteral obstruction, glomerulosclerosis, diabetic nephropathy, hyperhomocysteinemia, drug-induced nephrotoxicity, metal-induced nephrotoxicity, and urolithiasis. Novel H(2)S donors can be designed and applied in the treatment of common renal diseases. Frontiers Media S.A. 2020-11-19 /pmc/articles/PMC7751760/ /pubmed/33364941 http://dx.doi.org/10.3389/fphar.2020.564281 Text en Copyright © 2020 Ngowi, Sarfraz, Afzal, Hussain Khan, Khattak, Zhang, Li, Duan, Ji and Wu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Ngowi, Ebenezeri Erasto Sarfraz, Muhammad Afzal, Attia Khan, Nazeer Hussain Khattak, Saadullah Zhang, Xin Li, Tao Duan, Shao-Feng Ji, Xin-Ying Wu, Dong-Dong Roles of Hydrogen Sulfide Donors in Common Kidney Diseases |
title | Roles of Hydrogen Sulfide Donors in Common Kidney Diseases |
title_full | Roles of Hydrogen Sulfide Donors in Common Kidney Diseases |
title_fullStr | Roles of Hydrogen Sulfide Donors in Common Kidney Diseases |
title_full_unstemmed | Roles of Hydrogen Sulfide Donors in Common Kidney Diseases |
title_short | Roles of Hydrogen Sulfide Donors in Common Kidney Diseases |
title_sort | roles of hydrogen sulfide donors in common kidney diseases |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751760/ https://www.ncbi.nlm.nih.gov/pubmed/33364941 http://dx.doi.org/10.3389/fphar.2020.564281 |
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