Intercellular Receptor–Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes

[Image: see text] Nanoscale molecular clusters in cell membranes can serve as platforms to recruit membrane proteins for various biological functions. A central question is how these nanoclusters respond to physical contacts between cells. Using a statistical mechanics model and Monte Carlo simulati...

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Autores principales: Li, Long, Hu, Jinglei, Różycki, Bartosz, Song, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751893/
https://www.ncbi.nlm.nih.gov/pubmed/31858798
http://dx.doi.org/10.1021/acs.nanolett.9b04596
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author Li, Long
Hu, Jinglei
Różycki, Bartosz
Song, Fan
author_facet Li, Long
Hu, Jinglei
Różycki, Bartosz
Song, Fan
author_sort Li, Long
collection PubMed
description [Image: see text] Nanoscale molecular clusters in cell membranes can serve as platforms to recruit membrane proteins for various biological functions. A central question is how these nanoclusters respond to physical contacts between cells. Using a statistical mechanics model and Monte Carlo simulations, we explore how the adhesion of cell membranes affects the stability and coalescence of clusters enriched in receptor proteins. Our results show that intercellular receptor–ligand binding and membrane shape fluctuations can lead to receptor aggregation within the adhering membranes even if large-scale clusters are thermodynamically unstable in nonadhering membranes.
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spelling pubmed-77518932020-12-22 Intercellular Receptor–Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes Li, Long Hu, Jinglei Różycki, Bartosz Song, Fan Nano Lett [Image: see text] Nanoscale molecular clusters in cell membranes can serve as platforms to recruit membrane proteins for various biological functions. A central question is how these nanoclusters respond to physical contacts between cells. Using a statistical mechanics model and Monte Carlo simulations, we explore how the adhesion of cell membranes affects the stability and coalescence of clusters enriched in receptor proteins. Our results show that intercellular receptor–ligand binding and membrane shape fluctuations can lead to receptor aggregation within the adhering membranes even if large-scale clusters are thermodynamically unstable in nonadhering membranes. American Chemical Society 2019-12-20 2020-01-08 /pmc/articles/PMC7751893/ /pubmed/31858798 http://dx.doi.org/10.1021/acs.nanolett.9b04596 Text en This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Li, Long
Hu, Jinglei
Różycki, Bartosz
Song, Fan
Intercellular Receptor–Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes
title Intercellular Receptor–Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes
title_full Intercellular Receptor–Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes
title_fullStr Intercellular Receptor–Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes
title_full_unstemmed Intercellular Receptor–Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes
title_short Intercellular Receptor–Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes
title_sort intercellular receptor–ligand binding and thermal fluctuations facilitate receptor aggregation in adhering membranes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751893/
https://www.ncbi.nlm.nih.gov/pubmed/31858798
http://dx.doi.org/10.1021/acs.nanolett.9b04596
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