Rapid identification of anti-idiotypic mAbs with high affinity and diverse epitopes by rabbit single B-cell sorting-culture and cloning technology

The proactive generation of anti-idiotypic antibodies (anti-IDs) against therapeutic antibodies with desirable properties is an important step in pre-clinical and clinical assay development supporting their bioanalytical programs. Here, we describe a robust platform to generate anti-IDs using rabbit...

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Detalles Bibliográficos
Autores principales: Lin, WeiYu, Liang, Wei-Ching, Nguy, Trung, Maia, Mauricio, Tyagi, Tulika, Chiu, Cecilia, Hoi, Kam Hon, Chen, Yongmei, Wu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7751967/
https://www.ncbi.nlm.nih.gov/pubmed/33347473
http://dx.doi.org/10.1371/journal.pone.0244158

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