Developments in tandem ion mobility mass spectrometry

Ion Mobility (IM) coupled to mass spectrometry (MS) is a useful tool for separating species of interest out of small quantities of heterogenous mixtures via a combination of m/z and molecular shape. While tandem MS instruments are common, instruments which employ tandem IM are less so with the first...

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Detalles Bibliográficos
Autores principales: Eldrid, Charles, Thalassinos, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752082/
https://www.ncbi.nlm.nih.gov/pubmed/33336686
http://dx.doi.org/10.1042/BST20190788
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author Eldrid, Charles
Thalassinos, Konstantinos
author_facet Eldrid, Charles
Thalassinos, Konstantinos
author_sort Eldrid, Charles
collection PubMed
description Ion Mobility (IM) coupled to mass spectrometry (MS) is a useful tool for separating species of interest out of small quantities of heterogenous mixtures via a combination of m/z and molecular shape. While tandem MS instruments are common, instruments which employ tandem IM are less so with the first commercial IM–MS instrument capable of multiple IM selection rounds being released in 2019. Here we explore the history of tandem IM instruments, recent developments, the applications to biological systems and expected future directions.
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spelling pubmed-77520822021-01-05 Developments in tandem ion mobility mass spectrometry Eldrid, Charles Thalassinos, Konstantinos Biochem Soc Trans Review Articles Ion Mobility (IM) coupled to mass spectrometry (MS) is a useful tool for separating species of interest out of small quantities of heterogenous mixtures via a combination of m/z and molecular shape. While tandem MS instruments are common, instruments which employ tandem IM are less so with the first commercial IM–MS instrument capable of multiple IM selection rounds being released in 2019. Here we explore the history of tandem IM instruments, recent developments, the applications to biological systems and expected future directions. Portland Press Ltd. 2020-12-18 2020-12-18 /pmc/articles/PMC7752082/ /pubmed/33336686 http://dx.doi.org/10.1042/BST20190788 Text en © 2020 The Author(s) https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for this article was enabled by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC.
spellingShingle Review Articles
Eldrid, Charles
Thalassinos, Konstantinos
Developments in tandem ion mobility mass spectrometry
title Developments in tandem ion mobility mass spectrometry
title_full Developments in tandem ion mobility mass spectrometry
title_fullStr Developments in tandem ion mobility mass spectrometry
title_full_unstemmed Developments in tandem ion mobility mass spectrometry
title_short Developments in tandem ion mobility mass spectrometry
title_sort developments in tandem ion mobility mass spectrometry
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752082/
https://www.ncbi.nlm.nih.gov/pubmed/33336686
http://dx.doi.org/10.1042/BST20190788
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