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Evaluation of the diagnostic accuracy of a new point-of-care rapid test for SARS-CoV-2 virus detection
BACKGROUND: The easy access to a quick diagnosis of coronavirus disease 2019 (COVID-19) is a key point to improve the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to contain its spread. Up to now, laboratory real-time PCR is the standard of care, but requires a full...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752099/ https://www.ncbi.nlm.nih.gov/pubmed/33349261 http://dx.doi.org/10.1186/s12967-020-02651-y |
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author | Miscio, Leonardo Olivieri, Antonio Labonia, Francesco De Feo, Gianfranco Chiodini, Paolo Portella, Giuseppe Atripaldi, Luigi Parrella, Roberto Conenna, Rodolfo Buonaguro, Franco Maria Cavalcanti, Ernesta Ascierto, Paolo Botti, Gerardo Bianchi, Attilio |
author_facet | Miscio, Leonardo Olivieri, Antonio Labonia, Francesco De Feo, Gianfranco Chiodini, Paolo Portella, Giuseppe Atripaldi, Luigi Parrella, Roberto Conenna, Rodolfo Buonaguro, Franco Maria Cavalcanti, Ernesta Ascierto, Paolo Botti, Gerardo Bianchi, Attilio |
author_sort | Miscio, Leonardo |
collection | PubMed |
description | BACKGROUND: The easy access to a quick diagnosis of coronavirus disease 2019 (COVID-19) is a key point to improve the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to contain its spread. Up to now, laboratory real-time PCR is the standard of care, but requires a fully equipped laboratory and significant infrastructure. Consequently, new diagnostic tools are required. METHODS: In the present work, the diagnostic accuracy of the point-of-care rapid test "bKIT Virus Finder COVID-19" (Hyris (Ltd)) is evaluated by a retrospective and a prospective analysis on SARS CoV-2 samples previously assessed with an FDA “authorized for the emergency use—EUA” reference method. Descriptive statistics were used for the present study. RESULTS: Results obtained with the Hyris Kit are the same as that of standard laboratory-based real time PCR methods for all the analyzed samples. In addition, the Hyris Kit provides the test results in less than 2 h, a significantly shorter time compared to the reference methods, without the need of a fully equipped laboratory. CONCLUSIONS: To conclude, the Hyris kit represents a promising tool to improve the health surveillance and to increase the capacity of SARS-CoV-2 testing. |
format | Online Article Text |
id | pubmed-7752099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77520992020-12-22 Evaluation of the diagnostic accuracy of a new point-of-care rapid test for SARS-CoV-2 virus detection Miscio, Leonardo Olivieri, Antonio Labonia, Francesco De Feo, Gianfranco Chiodini, Paolo Portella, Giuseppe Atripaldi, Luigi Parrella, Roberto Conenna, Rodolfo Buonaguro, Franco Maria Cavalcanti, Ernesta Ascierto, Paolo Botti, Gerardo Bianchi, Attilio J Transl Med Research BACKGROUND: The easy access to a quick diagnosis of coronavirus disease 2019 (COVID-19) is a key point to improve the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to contain its spread. Up to now, laboratory real-time PCR is the standard of care, but requires a fully equipped laboratory and significant infrastructure. Consequently, new diagnostic tools are required. METHODS: In the present work, the diagnostic accuracy of the point-of-care rapid test "bKIT Virus Finder COVID-19" (Hyris (Ltd)) is evaluated by a retrospective and a prospective analysis on SARS CoV-2 samples previously assessed with an FDA “authorized for the emergency use—EUA” reference method. Descriptive statistics were used for the present study. RESULTS: Results obtained with the Hyris Kit are the same as that of standard laboratory-based real time PCR methods for all the analyzed samples. In addition, the Hyris Kit provides the test results in less than 2 h, a significantly shorter time compared to the reference methods, without the need of a fully equipped laboratory. CONCLUSIONS: To conclude, the Hyris kit represents a promising tool to improve the health surveillance and to increase the capacity of SARS-CoV-2 testing. BioMed Central 2020-12-21 /pmc/articles/PMC7752099/ /pubmed/33349261 http://dx.doi.org/10.1186/s12967-020-02651-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Miscio, Leonardo Olivieri, Antonio Labonia, Francesco De Feo, Gianfranco Chiodini, Paolo Portella, Giuseppe Atripaldi, Luigi Parrella, Roberto Conenna, Rodolfo Buonaguro, Franco Maria Cavalcanti, Ernesta Ascierto, Paolo Botti, Gerardo Bianchi, Attilio Evaluation of the diagnostic accuracy of a new point-of-care rapid test for SARS-CoV-2 virus detection |
title | Evaluation of the diagnostic accuracy of a new point-of-care rapid test for SARS-CoV-2 virus detection |
title_full | Evaluation of the diagnostic accuracy of a new point-of-care rapid test for SARS-CoV-2 virus detection |
title_fullStr | Evaluation of the diagnostic accuracy of a new point-of-care rapid test for SARS-CoV-2 virus detection |
title_full_unstemmed | Evaluation of the diagnostic accuracy of a new point-of-care rapid test for SARS-CoV-2 virus detection |
title_short | Evaluation of the diagnostic accuracy of a new point-of-care rapid test for SARS-CoV-2 virus detection |
title_sort | evaluation of the diagnostic accuracy of a new point-of-care rapid test for sars-cov-2 virus detection |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752099/ https://www.ncbi.nlm.nih.gov/pubmed/33349261 http://dx.doi.org/10.1186/s12967-020-02651-y |
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