Reprogramming to recover youthful epigenetic information and restore vision

Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed cause of ageing is the accumulation of epigenetic noise that disrupts gene expression patterns, leading to decreases in tissue function and regenerative capacity(1–3). Changes to DNA methylation patterns over tim...

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Detalles Bibliográficos
Autores principales: Lu, Yuancheng, Brommer, Benedikt, Tian, Xiao, Krishnan, Anitha, Meer, Margarita, Wang, Chen, Vera, Daniel L., Zeng, Qiurui, Yu, Doudou, Bonkowski, Michael S., Yang, Jae-Hyun, Zhou, Songlin, Hoffmann, Emma M., Karg, Margarete M., Schultz, Michael B., Kane, Alice E., Davidsohn, Noah, Korobkina, Ekaterina, Chwalek, Karolina, Rajman, Luis A., Church, George M., Hochedlinger, Konrad, Gladyshev, Vadim N., Horvath, Steve, Levine, Morgan E., Gregory-Ksander, Meredith S., Ksander, Bruce R., He, Zhigang, Sinclair, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752134/
https://www.ncbi.nlm.nih.gov/pubmed/33268865
http://dx.doi.org/10.1038/s41586-020-2975-4

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