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Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response

Vanishing white matter disease (VWM) is a severe leukodystrophy of the central nervous system caused by mutations in subunits of the eukaryotic initiation factor 2B complex (eIF2B). Current models only partially recapitulate key disease features, and pathophysiology is poorly understood. Through dev...

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Detalles Bibliográficos
Autores principales:	Keefe, Matthew D, Soderholm, Haille E, Shih, Hung-Yu, Stevenson, Tamara J, Glaittli, Kathryn A, Bowles, D Miranda, Scholl, Erika, Colby, Samuel, Merchant, Samer, Hsu, Edward W, Bonkowsky, Joshua L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752137/ https://www.ncbi.nlm.nih.gov/pubmed/33300869 http://dx.doi.org/10.7554/eLife.56319

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