Cholesterol-Induced Phenotypic Modulation of Smooth Muscle Cells to Macrophage/Fibroblast–like Cells Is Driven by an Unfolded Protein Response

Vascular smooth muscle cells (SMCs) dedifferentiate and initiate expression of macrophage markers with cholesterol exposure. This phenotypic switching is dependent on the transcription factor Klf4 (Krüppel-like factor 4). We investigated the molecular pathway by which cholesterol induces SMC phenoty...

Descripción completa

Detalles Bibliográficos
Autores principales: Chattopadhyay, Abhijnan, Kwartler, Callie S., Kaw, Kaveeta, Li, Yanming, Kaw, Anita, Chen, Jiyuan, LeMaire, Scott A., Shen, Ying H., Milewicz, Dianna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Basic Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752246/
https://www.ncbi.nlm.nih.gov/pubmed/33028096
http://dx.doi.org/10.1161/ATVBAHA.120.315164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752246/
https://www.ncbi.nlm.nih.gov/pubmed/33028096
http://dx.doi.org/10.1161/ATVBAHA.120.315164

Ejemplares similares