Screening of Concentration and Antimicrobial Effectiveness of Antimicrobial Preservative in Betastatin Besylate Nasal Spray

OBJECTIVE: To explore the optimal concentration and antimicrobial effectiveness of antimicrobial preservative in betastatin besylate nasal spray. METHODS: By using Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and Aspergillus niger as test strains, the antimicrob...

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Autores principales: Sun, Yanhong, Wang, Yinhuan, Zhou, Jianming, Zhou, Qingxue, Dong, Shilei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752262/
https://www.ncbi.nlm.nih.gov/pubmed/33415139
http://dx.doi.org/10.1155/2020/1315069
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author Sun, Yanhong
Wang, Yinhuan
Zhou, Jianming
Zhou, Qingxue
Dong, Shilei
author_facet Sun, Yanhong
Wang, Yinhuan
Zhou, Jianming
Zhou, Qingxue
Dong, Shilei
author_sort Sun, Yanhong
collection PubMed
description OBJECTIVE: To explore the optimal concentration and antimicrobial effectiveness of antimicrobial preservative in betastatin besylate nasal spray. METHODS: By using Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and Aspergillus niger as test strains, the antimicrobial effectiveness of betastatin besylate nasal spray containing different concentrations of antimicrobial preservative (0.02%, 0.0125%, and 0.005% benzalkonium chloride, respectively) was determined by using bacteriostatic effect test (Chinese Pharmacopoeia, 2015 edition). RESULTS: The antimicrobial effectiveness of betastatin besylate nasal spray containing 0.02% and 0.0125% benzalkonium chloride, respectively, complied with the regulations of Chinese Pharmacopoeia (2015 Edition) against five test strains. However, the antimicrobial effectiveness of betastatin besylate nasal spray containing 0.005% benzalkonium chloride against P. aeruginosa did not meet the requirements of Chinese Pharmacopoeia. CONCLUSION: Benzalkonium chloride at a concentration of 0.125% can be used as an added antimicrobial preservative in betastatin besylate nasal spray.
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spelling pubmed-77522622021-01-06 Screening of Concentration and Antimicrobial Effectiveness of Antimicrobial Preservative in Betastatin Besylate Nasal Spray Sun, Yanhong Wang, Yinhuan Zhou, Jianming Zhou, Qingxue Dong, Shilei Biomed Res Int Research Article OBJECTIVE: To explore the optimal concentration and antimicrobial effectiveness of antimicrobial preservative in betastatin besylate nasal spray. METHODS: By using Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and Aspergillus niger as test strains, the antimicrobial effectiveness of betastatin besylate nasal spray containing different concentrations of antimicrobial preservative (0.02%, 0.0125%, and 0.005% benzalkonium chloride, respectively) was determined by using bacteriostatic effect test (Chinese Pharmacopoeia, 2015 edition). RESULTS: The antimicrobial effectiveness of betastatin besylate nasal spray containing 0.02% and 0.0125% benzalkonium chloride, respectively, complied with the regulations of Chinese Pharmacopoeia (2015 Edition) against five test strains. However, the antimicrobial effectiveness of betastatin besylate nasal spray containing 0.005% benzalkonium chloride against P. aeruginosa did not meet the requirements of Chinese Pharmacopoeia. CONCLUSION: Benzalkonium chloride at a concentration of 0.125% can be used as an added antimicrobial preservative in betastatin besylate nasal spray. Hindawi 2020-12-12 /pmc/articles/PMC7752262/ /pubmed/33415139 http://dx.doi.org/10.1155/2020/1315069 Text en Copyright © 2020 Yanhong Sun et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sun, Yanhong
Wang, Yinhuan
Zhou, Jianming
Zhou, Qingxue
Dong, Shilei
Screening of Concentration and Antimicrobial Effectiveness of Antimicrobial Preservative in Betastatin Besylate Nasal Spray
title Screening of Concentration and Antimicrobial Effectiveness of Antimicrobial Preservative in Betastatin Besylate Nasal Spray
title_full Screening of Concentration and Antimicrobial Effectiveness of Antimicrobial Preservative in Betastatin Besylate Nasal Spray
title_fullStr Screening of Concentration and Antimicrobial Effectiveness of Antimicrobial Preservative in Betastatin Besylate Nasal Spray
title_full_unstemmed Screening of Concentration and Antimicrobial Effectiveness of Antimicrobial Preservative in Betastatin Besylate Nasal Spray
title_short Screening of Concentration and Antimicrobial Effectiveness of Antimicrobial Preservative in Betastatin Besylate Nasal Spray
title_sort screening of concentration and antimicrobial effectiveness of antimicrobial preservative in betastatin besylate nasal spray
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752262/
https://www.ncbi.nlm.nih.gov/pubmed/33415139
http://dx.doi.org/10.1155/2020/1315069
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