Cargando…

PPARα Agonist WY-14643 Relieves Neuropathic Pain through SIRT1-Mediated Deacetylation of NF-κB

Inflammation caused by neuropathy contributes to the development of neuropathic pain (NP), but the exact mechanism still needs to be understood. Peroxisome proliferator-activated receptor α (PPARα), an important inflammation regulator, might participate in the inflammation in NP. To explore the role...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wen, Wanshun, Wang, Jinlin, Zhang, Biyu, Wang, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752300/ https://www.ncbi.nlm.nih.gov/pubmed/33414819 http://dx.doi.org/10.1155/2020/6661642

Ejemplares similares

PPARα Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury
por: Pantazi, Eirini, et al.
Publicado: (2015)

WY14643 Increases Herpesvirus Replication and Inhibits IFNβ Production Independently of PPARα Expression
por: Tao, Lili, et al.
Publicado: (2023)

Nuclear Receptor PPARα Agonist Wy-14,643 Ameliorates Hepatic Cell Death in Hepatic IKKβ-Deficient Mice
por: Kim, Taehyeong, et al.
Publicado: (2017)

Characterization of WY 14,643 and its Complex with Aldose Reductase
por: Sawaya, Michael R., et al.
Publicado: (2016)

WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis
por: Briguglio, Enrico, et al.
Publicado: (2010)

Possible Role of Intestinal Fatty Acid Oxidation in the Eating-Inhibitory Effect of the PPAR-α Agonist Wy-14643 in High-Fat Diet Fed Rats
por: Karimian Azari, Elnaz, et al.
Publicado: (2013)

Chondroprotection of PPARα activation by WY14643 via autophagy involving Akt and ERK in LPS‐treated mouse chondrocytes and osteoarthritis model
por: Zhou, Yang, et al.
Publicado: (2019)

Protective Effects of Peroxisome Proliferator-Activated Receptor-α Agonist, Wy14643, on Hypoxia/Reoxygenation Injury in Primary Rat Hepatocytes
por: Chen, Ke, et al.
Publicado: (2012)

Correlation between thyroid hormone status and hepatic hyperplasia and hypertrophy caused by the peroxisome proliferator-activated receptor alpha agonist Wy-14,643
por: Wang, C, et al.
Publicado: (2004)

Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat.
por: Reddy, J. K., et al.
Publicado: (1978)

Multifaceted Mechanisms of WY-14643 to Stabilize the Blood-Brain Barrier in a Model of Traumatic Brain Injury
por: Neuhaus, Winfried, et al.
Publicado: (2017)

WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC
por: Wang, Rui, et al.
Publicado: (2022)

Comparison of the hepatic effects of nafenopin and WY-14,643 on peroxisome proliferation and cell replication in the rat and Syrian hamster.
por: Lake, B G, et al.
Publicado: (1993)

WY-14643 Regulates CYP1B1 Expression through Peroxisome Proliferator-Activated Receptor α-Mediated Signaling in Human Breast Cancer Cells
por: Hwang, Yong Pil, et al.
Publicado: (2019)

SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARγ2
por: Akter, Fatema, et al.
Publicado: (2021)

The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening
por: Deng, Zhantao, et al.
Publicado: (2017)

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity
por: Yang, Hongying, et al.
Publicado: (2012)

Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI Rats
por: Gao, Pengfei, et al.
Publicado: (2021)

Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway
por: Xu, Yingxi, et al.
Publicado: (2021)

Activating SIRT1 deacetylates NF-κB p65 to alleviate liver inflammation and fibrosis via inhibiting NLRP3 pathway in macrophages
por: He, Shuli, et al.
Publicado: (2023)

Bergenin, Acting as an Agonist of PPARγ, Ameliorates Experimental Colitis in Mice through Improving Expression of SIRT1, and Therefore Inhibiting NF-κB-Mediated Macrophage Activation
por: Wang, Kai, et al.
Publicado: (2018)

HDAC-mediated Deacetylation of NF-κB is Critical for Schwann cell Myelination
por: Chen, Ying, et al.
Publicado: (2011)

Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB p65 subunit
por: Wang, Xiaolei, et al.
Publicado: (2018)

The deacetylation of Foxk2 by Sirt1 reduces chemosensitivity to cisplatin
por: Wang, Xi‐wen, et al.
Publicado: (2021)

Chitosan Oligosaccharides Alleviate Colitis by Regulating Intestinal Microbiota and PPARγ/SIRT1-Mediated NF-κB Pathway
por: Guo, Congcong, et al.
Publicado: (2022)

Activation of SIRT6 Deacetylation by DNA Strand Breaks
por: Kang, Wenjia, et al.
Publicado: (2023)

The Role of NF-κB in PPARα-Mediated Hepatocarcinogenesis
por: Glauert, Howard P., et al.
Publicado: (2008)

SIRT3-Mediated CypD-K166 Deacetylation Alleviates Neuropathic Pain by Improving Mitochondrial Dysfunction and Inhibiting Oxidative Stress
por: Yan, Binbin, et al.
Publicado: (2022)

SIRT1 Regulates HIV Transcription via Tat Deacetylation
por: Pagans, Sara, et al.
Publicado: (2005)

SIRT1 links CIITA deacetylation to MHC II activation
por: Wu, Xiaoyan, et al.
Publicado: (2011)

Sirt1 Regulates Corneal Epithelial Migration by Deacetylating Cortactin
por: Lin, Yong, et al.
Publicado: (2022)

SIRT3 Regulates Clearance of Apoptotic Cardiomyocytes by Deacetylating Frataxin
por: Gao, Jing, et al.
Publicado: (2023)

Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis
por: Feng, Lifeng, et al.
Publicado: (2021)

SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability
por: Yu, Miao, et al.
Publicado: (2020)

VBS/VBF measurements (with photons Wy/Zy) at ATLAS and CMS
por: Smart, Ben Harry
Publicado: (2021)

Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression
por: Ito, Kazuhiro, et al.
Publicado: (2006)

Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages
por: Zheng, Yinghong, et al.
Publicado: (2021)

Scaffold-Based Pan-Agonist Design for the PPARα, PPARβ and PPARγ Receptors
por: Zhang, Li-Song, et al.
Publicado: (2012)

Pharmacological Treatment of Chemotherapy-Induced Neuropathic Pain: PPARγ Agonists as a Promising Tool
por: Quintão, Nara Lins Meira, et al.
Publicado: (2019)

Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK
por: Sandoval‐Rodriguez, Ana, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0k5c1gmr80j49ff9mmq46sdfsc