TP53 and PTEN as driver mutations in Zenker's carcinoma—a clinical presentation

Zenker carcinoma is still being treated empirically because of the lack of evidence‐ based guidelines. We report for the first time about the genetic examination of this rare entity. The revealed mutations show genetic similarities with HPV(‐)HNSCC which suggests that well‐known therapeutic strategi...

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Detalles Bibliográficos
Autores principales: Noel, Zsanett, Hoeller, Sylvia, Bihl, Michel, Muller, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752333/
https://www.ncbi.nlm.nih.gov/pubmed/33363824
http://dx.doi.org/10.1002/ccr3.3169
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author Noel, Zsanett
Hoeller, Sylvia
Bihl, Michel
Muller, Laurent
author_facet Noel, Zsanett
Hoeller, Sylvia
Bihl, Michel
Muller, Laurent
author_sort Noel, Zsanett
collection PubMed
description Zenker carcinoma is still being treated empirically because of the lack of evidence‐ based guidelines. We report for the first time about the genetic examination of this rare entity. The revealed mutations show genetic similarities with HPV(‐)HNSCC which suggests that well‐known therapeutic strategies may be applicable for this disease
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spelling pubmed-77523332020-12-23 TP53 and PTEN as driver mutations in Zenker's carcinoma—a clinical presentation Noel, Zsanett Hoeller, Sylvia Bihl, Michel Muller, Laurent Clin Case Rep Case Reports Zenker carcinoma is still being treated empirically because of the lack of evidence‐ based guidelines. We report for the first time about the genetic examination of this rare entity. The revealed mutations show genetic similarities with HPV(‐)HNSCC which suggests that well‐known therapeutic strategies may be applicable for this disease John Wiley and Sons Inc. 2020-09-01 /pmc/articles/PMC7752333/ /pubmed/33363824 http://dx.doi.org/10.1002/ccr3.3169 Text en © 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Noel, Zsanett
Hoeller, Sylvia
Bihl, Michel
Muller, Laurent
TP53 and PTEN as driver mutations in Zenker's carcinoma—a clinical presentation
title TP53 and PTEN as driver mutations in Zenker's carcinoma—a clinical presentation
title_full TP53 and PTEN as driver mutations in Zenker's carcinoma—a clinical presentation
title_fullStr TP53 and PTEN as driver mutations in Zenker's carcinoma—a clinical presentation
title_full_unstemmed TP53 and PTEN as driver mutations in Zenker's carcinoma—a clinical presentation
title_short TP53 and PTEN as driver mutations in Zenker's carcinoma—a clinical presentation
title_sort tp53 and pten as driver mutations in zenker's carcinoma—a clinical presentation
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752333/
https://www.ncbi.nlm.nih.gov/pubmed/33363824
http://dx.doi.org/10.1002/ccr3.3169
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AT mullerlaurent tp53andptenasdrivermutationsinzenkerscarcinomaaclinicalpresentation

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