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Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples: Effects on the Assisted Reproductive Outcomes
PURPOSE: To evaluate the influence of hepatitis B virus (HBV) infection in men of serodiscordant couples on the reproductive outcomes. MATERIALS AND METHODS: A total of 134 infertile couples were included in this retrospective single-center cohort study. Sixty-six couples had hepatitis B surface ant...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Sexual Medicine and Andrology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752521/ https://www.ncbi.nlm.nih.gov/pubmed/32009315 http://dx.doi.org/10.5534/wjmh.190121 |
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author | Cito, Gianmartin Coccia, Maria Elisabetta Fucci, Rossella Picone, Rita Cocci, Andrea Sessa, Maurizio Sessa, Francesco Rizzello, Francesca Micelli, Elisabetta Trotta, Michele Badolato, Laura Campi, Riccardo Criscuoli, Luciana Serni, Sergio Carini, Marco Natali, Alessandro |
author_facet | Cito, Gianmartin Coccia, Maria Elisabetta Fucci, Rossella Picone, Rita Cocci, Andrea Sessa, Maurizio Sessa, Francesco Rizzello, Francesca Micelli, Elisabetta Trotta, Michele Badolato, Laura Campi, Riccardo Criscuoli, Luciana Serni, Sergio Carini, Marco Natali, Alessandro |
author_sort | Cito, Gianmartin |
collection | PubMed |
description | PURPOSE: To evaluate the influence of hepatitis B virus (HBV) infection in men of serodiscordant couples on the reproductive outcomes. MATERIALS AND METHODS: A total of 134 infertile couples were included in this retrospective single-center cohort study. Sixty-six couples had hepatitis B surface antigen (HBsAg)-seropositive men and seronegative partners, while 68 couples were controls with both seronegative men and women. Overall, 134 fresh in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments were performed. As the main outcome measures, on the day of the fresh IVF/ICSI cycle, we assessed seminal parameters Before and after sperm preparation techniques. Two-pronuclear (2PN) fertilization, 1-2-3PN fertilization, cleavage, miscarriage, pregnancy and live birth rates were collected. RESULTS: No significant differences were found between groups in terms of oocytes retrieved, oocytes injected and embryos obtained (p=0.64, p=0.97, and p=0.40, respectively). The 2PN fertilization rate (FR) was comparable among groups (p=0.51). The 1-2-3PN FR was significantly lower in the HBsAg group than in the control group (66.6% vs. 69.7%, respectively). The clinical pregnancy per cycle, implantation, miscarriage and live birth rate were comparable between the HBsAg group and the control group. The median sperm concentration/ml and total sperm count, measured at baseline and after sperm preparation, was comparable between groups (p>0.05). There was a trend toward significant lower progressive motility (35.0% vs. 55.0%; p<0.05) in the HBsAg group at baseline and after sperm preparation (p<0.05). CONCLUSIONS: HBV infected men have the same chance to became father, compared to seronegative patients. |
format | Online Article Text |
id | pubmed-7752521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society for Sexual Medicine and Andrology |
record_format | MEDLINE/PubMed |
spelling | pubmed-77525212021-01-05 Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples: Effects on the Assisted Reproductive Outcomes Cito, Gianmartin Coccia, Maria Elisabetta Fucci, Rossella Picone, Rita Cocci, Andrea Sessa, Maurizio Sessa, Francesco Rizzello, Francesca Micelli, Elisabetta Trotta, Michele Badolato, Laura Campi, Riccardo Criscuoli, Luciana Serni, Sergio Carini, Marco Natali, Alessandro World J Mens Health Original Article PURPOSE: To evaluate the influence of hepatitis B virus (HBV) infection in men of serodiscordant couples on the reproductive outcomes. MATERIALS AND METHODS: A total of 134 infertile couples were included in this retrospective single-center cohort study. Sixty-six couples had hepatitis B surface antigen (HBsAg)-seropositive men and seronegative partners, while 68 couples were controls with both seronegative men and women. Overall, 134 fresh in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments were performed. As the main outcome measures, on the day of the fresh IVF/ICSI cycle, we assessed seminal parameters Before and after sperm preparation techniques. Two-pronuclear (2PN) fertilization, 1-2-3PN fertilization, cleavage, miscarriage, pregnancy and live birth rates were collected. RESULTS: No significant differences were found between groups in terms of oocytes retrieved, oocytes injected and embryos obtained (p=0.64, p=0.97, and p=0.40, respectively). The 2PN fertilization rate (FR) was comparable among groups (p=0.51). The 1-2-3PN FR was significantly lower in the HBsAg group than in the control group (66.6% vs. 69.7%, respectively). The clinical pregnancy per cycle, implantation, miscarriage and live birth rate were comparable between the HBsAg group and the control group. The median sperm concentration/ml and total sperm count, measured at baseline and after sperm preparation, was comparable between groups (p>0.05). There was a trend toward significant lower progressive motility (35.0% vs. 55.0%; p<0.05) in the HBsAg group at baseline and after sperm preparation (p<0.05). CONCLUSIONS: HBV infected men have the same chance to became father, compared to seronegative patients. Korean Society for Sexual Medicine and Andrology 2021-01 2019-12-17 /pmc/articles/PMC7752521/ /pubmed/32009315 http://dx.doi.org/10.5534/wjmh.190121 Text en Copyright © 2021 Korean Society for Sexual Medicine and Andrology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Cito, Gianmartin Coccia, Maria Elisabetta Fucci, Rossella Picone, Rita Cocci, Andrea Sessa, Maurizio Sessa, Francesco Rizzello, Francesca Micelli, Elisabetta Trotta, Michele Badolato, Laura Campi, Riccardo Criscuoli, Luciana Serni, Sergio Carini, Marco Natali, Alessandro Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples: Effects on the Assisted Reproductive Outcomes |
title | Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples: Effects on the Assisted Reproductive Outcomes |
title_full | Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples: Effects on the Assisted Reproductive Outcomes |
title_fullStr | Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples: Effects on the Assisted Reproductive Outcomes |
title_full_unstemmed | Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples: Effects on the Assisted Reproductive Outcomes |
title_short | Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples: Effects on the Assisted Reproductive Outcomes |
title_sort | hepatitis b surface antigen seropositive men in serodiscordant couples: effects on the assisted reproductive outcomes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752521/ https://www.ncbi.nlm.nih.gov/pubmed/32009315 http://dx.doi.org/10.5534/wjmh.190121 |
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