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Cisplatin's dual-effect on the circadian clock triggers proliferation and apoptosis
The circadian clock, which generates the internal daily rhythm largely mediated through release of melatonin, can be disrupted in various ways. Multiple factors result in a disruption of the circadian cycle in the clinical context, of interest are anti-cancer drugs such as cisplatin. Cisplatin modul...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752721/ https://www.ncbi.nlm.nih.gov/pubmed/33364523 http://dx.doi.org/10.1016/j.nbscr.2020.100054 |
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author | Sadiq, Zuhair Varghese, Elizabeth Büsselberg, Dietrich |
author_facet | Sadiq, Zuhair Varghese, Elizabeth Büsselberg, Dietrich |
author_sort | Sadiq, Zuhair |
collection | PubMed |
description | The circadian clock, which generates the internal daily rhythm largely mediated through release of melatonin, can be disrupted in various ways. Multiple factors result in a disruption of the circadian cycle in the clinical context, of interest are anti-cancer drugs such as cisplatin. Cisplatin modulates the circadian clock through two mechanisms: 1) the circadian clock control of DNA excision repair and 2) the effect of circadian clock disruption on apoptosis. Cisplatin can stimulate multiple classified molecules, including DNA repair factors, DNA damage recognition factors and transcription factors in drug resistance and cisplatin-induced signal transduction. These factors interact with each other and can be transformed by DNA damage. Hence, these molecular interactions are intimately involved in cell proliferation and damage-induced apoptosis. Cisplatin has a dual-effect on circadian genes: upregulation of CLOCK expression causes an increase in proliferation but upregulation of BMAL1 expression causes an increase in apoptosis. Therefore, the interference of circadian genes by cisplatin can have multiple, opposing effects on apoptosis and cell proliferation, which may have unintended pro-cancer effects. Melatonin and intracellular Ca(2+) also have a dual-effect on cell proliferation and apoptosis and can disrupt circadian rhythms. |
format | Online Article Text |
id | pubmed-7752721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-77527212020-12-23 Cisplatin's dual-effect on the circadian clock triggers proliferation and apoptosis Sadiq, Zuhair Varghese, Elizabeth Büsselberg, Dietrich Neurobiol Sleep Circadian Rhythms Review Article The circadian clock, which generates the internal daily rhythm largely mediated through release of melatonin, can be disrupted in various ways. Multiple factors result in a disruption of the circadian cycle in the clinical context, of interest are anti-cancer drugs such as cisplatin. Cisplatin modulates the circadian clock through two mechanisms: 1) the circadian clock control of DNA excision repair and 2) the effect of circadian clock disruption on apoptosis. Cisplatin can stimulate multiple classified molecules, including DNA repair factors, DNA damage recognition factors and transcription factors in drug resistance and cisplatin-induced signal transduction. These factors interact with each other and can be transformed by DNA damage. Hence, these molecular interactions are intimately involved in cell proliferation and damage-induced apoptosis. Cisplatin has a dual-effect on circadian genes: upregulation of CLOCK expression causes an increase in proliferation but upregulation of BMAL1 expression causes an increase in apoptosis. Therefore, the interference of circadian genes by cisplatin can have multiple, opposing effects on apoptosis and cell proliferation, which may have unintended pro-cancer effects. Melatonin and intracellular Ca(2+) also have a dual-effect on cell proliferation and apoptosis and can disrupt circadian rhythms. Elsevier 2020-07-30 /pmc/articles/PMC7752721/ /pubmed/33364523 http://dx.doi.org/10.1016/j.nbscr.2020.100054 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Article Sadiq, Zuhair Varghese, Elizabeth Büsselberg, Dietrich Cisplatin's dual-effect on the circadian clock triggers proliferation and apoptosis |
title | Cisplatin's dual-effect on the circadian clock triggers proliferation and apoptosis |
title_full | Cisplatin's dual-effect on the circadian clock triggers proliferation and apoptosis |
title_fullStr | Cisplatin's dual-effect on the circadian clock triggers proliferation and apoptosis |
title_full_unstemmed | Cisplatin's dual-effect on the circadian clock triggers proliferation and apoptosis |
title_short | Cisplatin's dual-effect on the circadian clock triggers proliferation and apoptosis |
title_sort | cisplatin's dual-effect on the circadian clock triggers proliferation and apoptosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752721/ https://www.ncbi.nlm.nih.gov/pubmed/33364523 http://dx.doi.org/10.1016/j.nbscr.2020.100054 |
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