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Evaluation of the MC4R gene across eMERGE network identifies many unreported obesity-associated variants

BACKGROUND/OBJECTIVES: Melanocortin-4 receptor (MC4R) plays an essential role in food intake and energy homeostasis. More than 170 MC4R variants have been described over the past two decades, with conflicting reports regarding the prevalence and phenotypic effects of these variants in diverse cohort...

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Detalles Bibliográficos
Autores principales:	Namjou, Bahram, Stanaway, Ian B., Lingren, Todd, Mentch, Frank D., Benoit, Barbara, Dikilitas, Ozan, Niu, Xinnan, Shang, Ning, Shoemaker, Ashley H., Carey, David J., Mirshahi, Tooraj, Singh, Rajbir, Nestor, Jordan G., Hakonarson, Hakon, Denny, Joshua C., Crosslin, David R., Jarvik, Gail P., Kullo, Iftikhar J., Williams, Marc S., Harley, John B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752751/ https://www.ncbi.nlm.nih.gov/pubmed/32952152 http://dx.doi.org/10.1038/s41366-020-00675-4

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