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High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort
BACKGROUND/OBJECTIVES: Maternal glycaemia promotes fetal adiposity. Inositol, an insulin sensitizer, has been trialled for gestational diabetes prevention. The placenta has been implicated in how maternal hyperglycaemia generates fetal pathophysiology, but no studies have examined whether placental...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752752/ https://www.ncbi.nlm.nih.gov/pubmed/32433604 http://dx.doi.org/10.1038/s41366-020-0596-5 |
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author | Chu, Anne H. Y. Tint, Mya T. Chang, Hsin F. Wong, Gerard Yuan, Wen Lun Tull, Dedreia Nijagal, Brunda Narayana, Vinod K. Meikle, Peter J. Chang, Kenneth T. E. Lewis, Rohan M. Chi, Claudia Yap, Fabian K. P. Tan, Kok Hian Shek, Lynette P. Chong, Yap-Seng Gluckman, Peter D. Lee, Yung Seng Fortier, Marielle V. Godfrey, Keith M. Eriksson, Johan G. Karnani, Neerja Chan, Shiao-Yng |
author_facet | Chu, Anne H. Y. Tint, Mya T. Chang, Hsin F. Wong, Gerard Yuan, Wen Lun Tull, Dedreia Nijagal, Brunda Narayana, Vinod K. Meikle, Peter J. Chang, Kenneth T. E. Lewis, Rohan M. Chi, Claudia Yap, Fabian K. P. Tan, Kok Hian Shek, Lynette P. Chong, Yap-Seng Gluckman, Peter D. Lee, Yung Seng Fortier, Marielle V. Godfrey, Keith M. Eriksson, Johan G. Karnani, Neerja Chan, Shiao-Yng |
author_sort | Chu, Anne H. Y. |
collection | PubMed |
description | BACKGROUND/OBJECTIVES: Maternal glycaemia promotes fetal adiposity. Inositol, an insulin sensitizer, has been trialled for gestational diabetes prevention. The placenta has been implicated in how maternal hyperglycaemia generates fetal pathophysiology, but no studies have examined whether placental inositol biology is altered with maternal hyperglycaemia, nor whether such alterations impact fetal physiology. We aimed to investigate whether the effects of maternal glycaemia on offspring birthweight and adiposity at birth differed across placental inositol levels. METHODS: Using longitudinal data from the Growing Up in Singapore Towards healthy Outcomes cohort, maternal fasting glucose (FPG) and 2-hour plasma glucose (2hPG) were obtained in pregnant women by a 75-g oral glucose tolerance test around 26 weeks’ gestation. Relative placental inositol was quantified by liquid chromatography-mass spectrometry. Primary outcomes were birthweight (n = 884) and abdominal adipose tissue (AAT) volumes measured by neonatal MRI scanning in a subset (n = 262) of term singleton pregnancies. Multiple linear regression analyses were performed. RESULTS: Placental inositol was lower in those with higher 2hPG, no exposure to tobacco smoke antenatally, with vaginal delivery and shorter gestation. Positive associations of FPG with birthweight (adjusted β [95% CI] 164.8 g [109.1, 220.5]) and AAT (17.3 ml [11.9, 22.6] per mmol glucose) were observed, with significant interactions between inositol tertiles and FPG in relation to these outcomes (p < 0.05). Stratification by inositol tertiles showed that each mmol/L increase in FPG was associated with increased birthweight and AAT volume among cases within the lowest (birthweight = 174.2 g [81.2, 267.2], AAT = 21.0 ml [13.1, 28.8]) and middle inositol tertiles (birthweight = 202.0 g [103.8, 300.1], AAT = 19.7 ml [9.7, 29.7]). However, no significant association was found among cases within the highest tertile (birthweight = 81.0 g [−21.2, 183.2], AAT = 0.8 ml [−8.4, 10.0]). CONCLUSIONS: High placental inositol may protect the fetus from the pro-adipogenic effects of maternal glycaemia. Studies are warranted to investigate whether prenatal inositol supplementation can increase placental inositol and reduce fetal adiposity. |
format | Online Article Text |
id | pubmed-7752752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77527522020-12-29 High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort Chu, Anne H. Y. Tint, Mya T. Chang, Hsin F. Wong, Gerard Yuan, Wen Lun Tull, Dedreia Nijagal, Brunda Narayana, Vinod K. Meikle, Peter J. Chang, Kenneth T. E. Lewis, Rohan M. Chi, Claudia Yap, Fabian K. P. Tan, Kok Hian Shek, Lynette P. Chong, Yap-Seng Gluckman, Peter D. Lee, Yung Seng Fortier, Marielle V. Godfrey, Keith M. Eriksson, Johan G. Karnani, Neerja Chan, Shiao-Yng Int J Obes (Lond) Article BACKGROUND/OBJECTIVES: Maternal glycaemia promotes fetal adiposity. Inositol, an insulin sensitizer, has been trialled for gestational diabetes prevention. The placenta has been implicated in how maternal hyperglycaemia generates fetal pathophysiology, but no studies have examined whether placental inositol biology is altered with maternal hyperglycaemia, nor whether such alterations impact fetal physiology. We aimed to investigate whether the effects of maternal glycaemia on offspring birthweight and adiposity at birth differed across placental inositol levels. METHODS: Using longitudinal data from the Growing Up in Singapore Towards healthy Outcomes cohort, maternal fasting glucose (FPG) and 2-hour plasma glucose (2hPG) were obtained in pregnant women by a 75-g oral glucose tolerance test around 26 weeks’ gestation. Relative placental inositol was quantified by liquid chromatography-mass spectrometry. Primary outcomes were birthweight (n = 884) and abdominal adipose tissue (AAT) volumes measured by neonatal MRI scanning in a subset (n = 262) of term singleton pregnancies. Multiple linear regression analyses were performed. RESULTS: Placental inositol was lower in those with higher 2hPG, no exposure to tobacco smoke antenatally, with vaginal delivery and shorter gestation. Positive associations of FPG with birthweight (adjusted β [95% CI] 164.8 g [109.1, 220.5]) and AAT (17.3 ml [11.9, 22.6] per mmol glucose) were observed, with significant interactions between inositol tertiles and FPG in relation to these outcomes (p < 0.05). Stratification by inositol tertiles showed that each mmol/L increase in FPG was associated with increased birthweight and AAT volume among cases within the lowest (birthweight = 174.2 g [81.2, 267.2], AAT = 21.0 ml [13.1, 28.8]) and middle inositol tertiles (birthweight = 202.0 g [103.8, 300.1], AAT = 19.7 ml [9.7, 29.7]). However, no significant association was found among cases within the highest tertile (birthweight = 81.0 g [−21.2, 183.2], AAT = 0.8 ml [−8.4, 10.0]). CONCLUSIONS: High placental inositol may protect the fetus from the pro-adipogenic effects of maternal glycaemia. Studies are warranted to investigate whether prenatal inositol supplementation can increase placental inositol and reduce fetal adiposity. Nature Publishing Group UK 2020-05-20 2021 /pmc/articles/PMC7752752/ /pubmed/32433604 http://dx.doi.org/10.1038/s41366-020-0596-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Chu, Anne H. Y. Tint, Mya T. Chang, Hsin F. Wong, Gerard Yuan, Wen Lun Tull, Dedreia Nijagal, Brunda Narayana, Vinod K. Meikle, Peter J. Chang, Kenneth T. E. Lewis, Rohan M. Chi, Claudia Yap, Fabian K. P. Tan, Kok Hian Shek, Lynette P. Chong, Yap-Seng Gluckman, Peter D. Lee, Yung Seng Fortier, Marielle V. Godfrey, Keith M. Eriksson, Johan G. Karnani, Neerja Chan, Shiao-Yng High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort |
title | High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort |
title_full | High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort |
title_fullStr | High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort |
title_full_unstemmed | High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort |
title_short | High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort |
title_sort | high placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the gusto cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752752/ https://www.ncbi.nlm.nih.gov/pubmed/32433604 http://dx.doi.org/10.1038/s41366-020-0596-5 |
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