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Personality Disorder and Physical Health Comorbidities: A Link With Bone Health?

We examined whether personality disorders (PDs) (any, cluster A/B/C) were associated with bone mineral density (BMD) in a population-based sample of Australian women (n = 696). Personality and mood disorders were assessed using semi-structured diagnostic interviews. BMD was measured at the spine, hi...

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Autores principales: Williams, Lana J., Quirk, Shae E., Koivumaa-Honkanen, Heli, Honkanen, Risto, Pasco, Julie A., Stuart, Amanda L., Kavanagh, Bianca E., Heikkinen, Jeremi, Berk, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752862/
https://www.ncbi.nlm.nih.gov/pubmed/33363487
http://dx.doi.org/10.3389/fpsyt.2020.602342
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author Williams, Lana J.
Quirk, Shae E.
Koivumaa-Honkanen, Heli
Honkanen, Risto
Pasco, Julie A.
Stuart, Amanda L.
Kavanagh, Bianca E.
Heikkinen, Jeremi
Berk, Michael
author_facet Williams, Lana J.
Quirk, Shae E.
Koivumaa-Honkanen, Heli
Honkanen, Risto
Pasco, Julie A.
Stuart, Amanda L.
Kavanagh, Bianca E.
Heikkinen, Jeremi
Berk, Michael
author_sort Williams, Lana J.
collection PubMed
description We examined whether personality disorders (PDs) (any, cluster A/B/C) were associated with bone mineral density (BMD) in a population-based sample of Australian women (n = 696). Personality and mood disorders were assessed using semi-structured diagnostic interviews. BMD was measured at the spine, hip, and total body using dual-energy x-ray absorptiometry (GE-Lunar Prodigy). Anthropometrics, medication use, physical conditions, and lifestyle factors were documented. The association between PDs (any, cluster A/B/C) and BMD (spine/hip/total body) was examined with multiple linear regression models. The best models were identified by backward elimination including age, weight, physical activity, smoking status, alcohol consumption, dietary calcium intake, mood disorders, physical multimorbidity, socioeconomic status, and medications affecting bone. The variables were retained in the model if p < 0.05. All potential interactions in final models were tested. Those with cluster A PD, compared to those without, had 6.7% lower hip BMD [age, weight adjusted mean 0.853 (95% CI 0.803–0.903) vs. 0.910 (95% CI 0.901–0.919) g/cm(2), p = 0.027] and 3.4% lower total body BMD [age, weight, smoking, alcohol, calcium adjusted mean 1.102 (95% CI 1.064–1.140) vs. 1.139 (95% CI 1.128–1.150) g/cm(2), p = 0.056]. No associations were observed between cluster B/C PDs and hip/total body BMD or between any of the PD clusters and spine BMD. To our knowledge, this study is the first to investigate the bone health of women with PD in a population-based sample. Given the paucity of literature, replication and longitudinal research including the examination of underlying mechanisms and sex differences are warranted.
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spelling pubmed-77528622020-12-23 Personality Disorder and Physical Health Comorbidities: A Link With Bone Health? Williams, Lana J. Quirk, Shae E. Koivumaa-Honkanen, Heli Honkanen, Risto Pasco, Julie A. Stuart, Amanda L. Kavanagh, Bianca E. Heikkinen, Jeremi Berk, Michael Front Psychiatry Psychiatry We examined whether personality disorders (PDs) (any, cluster A/B/C) were associated with bone mineral density (BMD) in a population-based sample of Australian women (n = 696). Personality and mood disorders were assessed using semi-structured diagnostic interviews. BMD was measured at the spine, hip, and total body using dual-energy x-ray absorptiometry (GE-Lunar Prodigy). Anthropometrics, medication use, physical conditions, and lifestyle factors were documented. The association between PDs (any, cluster A/B/C) and BMD (spine/hip/total body) was examined with multiple linear regression models. The best models were identified by backward elimination including age, weight, physical activity, smoking status, alcohol consumption, dietary calcium intake, mood disorders, physical multimorbidity, socioeconomic status, and medications affecting bone. The variables were retained in the model if p < 0.05. All potential interactions in final models were tested. Those with cluster A PD, compared to those without, had 6.7% lower hip BMD [age, weight adjusted mean 0.853 (95% CI 0.803–0.903) vs. 0.910 (95% CI 0.901–0.919) g/cm(2), p = 0.027] and 3.4% lower total body BMD [age, weight, smoking, alcohol, calcium adjusted mean 1.102 (95% CI 1.064–1.140) vs. 1.139 (95% CI 1.128–1.150) g/cm(2), p = 0.056]. No associations were observed between cluster B/C PDs and hip/total body BMD or between any of the PD clusters and spine BMD. To our knowledge, this study is the first to investigate the bone health of women with PD in a population-based sample. Given the paucity of literature, replication and longitudinal research including the examination of underlying mechanisms and sex differences are warranted. Frontiers Media S.A. 2020-12-08 /pmc/articles/PMC7752862/ /pubmed/33363487 http://dx.doi.org/10.3389/fpsyt.2020.602342 Text en Copyright © 2020 Williams, Quirk, Koivumaa-Honkanen, Honkanen, Pasco, Stuart, Kavanagh, Heikkinen and Berk. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Williams, Lana J.
Quirk, Shae E.
Koivumaa-Honkanen, Heli
Honkanen, Risto
Pasco, Julie A.
Stuart, Amanda L.
Kavanagh, Bianca E.
Heikkinen, Jeremi
Berk, Michael
Personality Disorder and Physical Health Comorbidities: A Link With Bone Health?
title Personality Disorder and Physical Health Comorbidities: A Link With Bone Health?
title_full Personality Disorder and Physical Health Comorbidities: A Link With Bone Health?
title_fullStr Personality Disorder and Physical Health Comorbidities: A Link With Bone Health?
title_full_unstemmed Personality Disorder and Physical Health Comorbidities: A Link With Bone Health?
title_short Personality Disorder and Physical Health Comorbidities: A Link With Bone Health?
title_sort personality disorder and physical health comorbidities: a link with bone health?
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752862/
https://www.ncbi.nlm.nih.gov/pubmed/33363487
http://dx.doi.org/10.3389/fpsyt.2020.602342
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