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The Usage of Human IGHJ Genes Follows a Particular Non-random Selection: The Recombination Signal Sequence May Affect the Usage of Human IGHJ Genes

The formation of the B cell receptor (BCR) heavy chain variable region is derived from the germline V(D)J gene rearrangement according to the “12/23” rule and the “beyond 12/23” rule. The usage frequency of each V(D)J gene in the peripheral BCR repertoires is related to the initial recombination, se...

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Detalles Bibliográficos
Autores principales:	Shi, Bin, Dong, Xiaoheng, Ma, Qingqing, Sun, Suhong, Ma, Long, Yu, Jiang, Wang, Xiaomei, Pan, Juan, He, Xiaoyan, Su, Danhua, Yao, Xinsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753069/ https://www.ncbi.nlm.nih.gov/pubmed/33363565 http://dx.doi.org/10.3389/fgene.2020.524413

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