Chemical constituents of Chaenomeles sinensis twigs and their biological activity

A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate 1 was determined by conventional 1D and 2D NMR data analysis, E...

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Detalles Bibliográficos
Autores principales: Cha, Joon Min, Kim, Dong Hyun, Subedi, Lalita, Khan, Zahra, Choi, Sang Un, Kim, Sun Yeou, Kim, Chung Sub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2020
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753107/
https://www.ncbi.nlm.nih.gov/pubmed/33414855
http://dx.doi.org/10.3762/bjoc.16.257
Descripción
Sumario:A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate 1 was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher’s method, and LC–MS analysis. The characterized compounds’ biological effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated.

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