Chemical constituents of Chaenomeles sinensis twigs and their biological activity

A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate 1 was determined by conventional 1D and 2D NMR data analysis, E...

Descripción completa

Detalles Bibliográficos
Autores principales: Cha, Joon Min, Kim, Dong Hyun, Subedi, Lalita, Khan, Zahra, Choi, Sang Un, Kim, Sun Yeou, Kim, Chung Sub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2020
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753107/
https://www.ncbi.nlm.nih.gov/pubmed/33414855
http://dx.doi.org/10.3762/bjoc.16.257
_version_ 1783625999849619456
author Cha, Joon Min
Kim, Dong Hyun
Subedi, Lalita
Khan, Zahra
Choi, Sang Un
Kim, Sun Yeou
Kim, Chung Sub
author_facet Cha, Joon Min
Kim, Dong Hyun
Subedi, Lalita
Khan, Zahra
Choi, Sang Un
Kim, Sun Yeou
Kim, Chung Sub
author_sort Cha, Joon Min
collection PubMed
description A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate 1 was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher’s method, and LC–MS analysis. The characterized compounds’ biological effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated.
format Online
Article
Text
id pubmed-7753107
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Beilstein-Institut
record_format MEDLINE/PubMed
spelling pubmed-77531072021-01-06 Chemical constituents of Chaenomeles sinensis twigs and their biological activity Cha, Joon Min Kim, Dong Hyun Subedi, Lalita Khan, Zahra Choi, Sang Un Kim, Sun Yeou Kim, Chung Sub Beilstein J Org Chem Letter A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate 1 was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher’s method, and LC–MS analysis. The characterized compounds’ biological effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated. Beilstein-Institut 2020-12-17 /pmc/articles/PMC7753107/ /pubmed/33414855 http://dx.doi.org/10.3762/bjoc.16.257 Text en Copyright © 2020, Cha et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/terms/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms/terms)
spellingShingle Letter
Cha, Joon Min
Kim, Dong Hyun
Subedi, Lalita
Khan, Zahra
Choi, Sang Un
Kim, Sun Yeou
Kim, Chung Sub
Chemical constituents of Chaenomeles sinensis twigs and their biological activity
title Chemical constituents of Chaenomeles sinensis twigs and their biological activity
title_full Chemical constituents of Chaenomeles sinensis twigs and their biological activity
title_fullStr Chemical constituents of Chaenomeles sinensis twigs and their biological activity
title_full_unstemmed Chemical constituents of Chaenomeles sinensis twigs and their biological activity
title_short Chemical constituents of Chaenomeles sinensis twigs and their biological activity
title_sort chemical constituents of chaenomeles sinensis twigs and their biological activity
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753107/
https://www.ncbi.nlm.nih.gov/pubmed/33414855
http://dx.doi.org/10.3762/bjoc.16.257
work_keys_str_mv AT chajoonmin chemicalconstituentsofchaenomelessinensistwigsandtheirbiologicalactivity
AT kimdonghyun chemicalconstituentsofchaenomelessinensistwigsandtheirbiologicalactivity
AT subedilalita chemicalconstituentsofchaenomelessinensistwigsandtheirbiologicalactivity
AT khanzahra chemicalconstituentsofchaenomelessinensistwigsandtheirbiologicalactivity
AT choisangun chemicalconstituentsofchaenomelessinensistwigsandtheirbiologicalactivity
AT kimsunyeou chemicalconstituentsofchaenomelessinensistwigsandtheirbiologicalactivity
AT kimchungsub chemicalconstituentsofchaenomelessinensistwigsandtheirbiologicalactivity

Ejemplares similares